Phenotypes associated with this allele

• Allele Symbol: Hoxc13^N
• Allele Name: naked
• Allele ID: MGI:1861361
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxc13^N/Hoxc13^N	Not Specified	MGI:3609134
ht2	Hoxc13^N/Hoxc13^+	Not Specified	MGI:3609056

Genotype
MGI:3609134

hm1

• Allelic Composition: Hoxc13^N/Hoxc13^N
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:14908 )

postnatal lethality ( J:6403 )

• often die within 10 days of birth

muscle

muscle degeneration ( J:30359 )

growth/size/body

decreased body size ( J:30359 )

• mice that survive are runted and require ground food pellets

integument

hairless ( J:6403 )

• mice that survive develop a growth of fine hair on head, feet, and tail

abnormal hair texture ( J:14940 )

brittle hair ( J:14940 )

• hair breaks soon after formation

toenail hyperkeratosis ( J:30359 )

absent vibrissae ( J:30359 )

• not present at birth

abnormal hair cycle ( J:6403 )

• mice never grow a complete coat

• there are cycles of regeneration and loss but new hair breaks prematurely

Genotype
MGI:3609056

ht2

• Allelic Composition: Hoxc13^N/Hoxc13⁺
• Genetic Background: Not Specified

integument

abnormal coat appearance ( J:14908 )

• hair breakage and regeneration is not uniform so mice are mosaic for bare and haired patches

abnormal hair texture ( J:14908 )

brittle hair ( J:14908 )

• hair begins to break at 10 to 14 days due to incomplete keratinization

• hair breakage and regeneration occurs in cycles

abnormal hair shaft morphology ( J:6403 , J:14908 , J:30359 )

• hair shafts have a deficiency in or entirely lack a cuticle (J:30359)

abnormal hair cuticle ( J:30359 )

• may be deficient or absent

abnormal hair cycle ( J:6403 )

abnormal epidermal layer morphology ( J:6403 )

• dermal-epidermal recombination experiments indicated that the epidermis of this mutant is abnormal

• one or more weak places result in breakage or longitudinal fissures