Phenotypes associated with this allele

• Allele Symbol: Rf
• Allele Name: rib fusion
• Allele ID: MGI:1861224
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rf/Rf	involves: 129/RrSv	MGI:5637372
ht2	Rf/Rf^+	either: (involves: 129/RrSv * A/J) or (involves: 129/RrSv * SWV)	MGI:5637380
ht3	Rf/Rf^+	involves: 129/RrSv	MGI:5637356

Genotype
MGI:5637372

hm1

• Allelic Composition: Rf/Rf
• Genetic Background: involves: 129/RrSv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryonic growth retardation ( J:278 )

abnormal embryonic tissue morphology ( J:278 )

• noticeable by E9

abnormal neural plate morphology ( J:278 )

• noticeable by E9

absent somites ( J:278 )

• noticeable by E9

growth/size/body

embryonic growth retardation ( J:278 )

decreased birth body size ( J:278 )

• bodies are shorter and wider than normal

nervous system

abnormal neural plate morphology ( J:278 )

• noticeable by E9

exencephaly ( J:278 )

• not typical of all mutants

mortality/aging

perinatal lethality, complete penetrance ( J:278 )

limbs/digits/tail

abnormal tail length ( J:278 )

• mutant mice are tailless or have vestigial tails

absent tail ( J:278 )

vestigial tail ( J:278 )

skeleton

abnormal axial skeleton morphology ( J:278 )

• mutant mice have extensive anomalies

abnormal vertebral column morphology ( J:278 )

• extensive fractures and fusions make alignment problematic

Genotype
MGI:5637380

ht2

• Allelic Composition: Rf/Rf⁺
• Genetic Background: either: (involves: 129/RrSv * A/J) or (involves: 129/RrSv * SWV)

nervous system

exencephaly ( J:6443 )

• heterozygous mutant mice develop exencephaly more often than wild-type mice when treated with teratogenic doses of insulin

Genotype
MGI:5637356

ht3

• Allelic Composition: Rf/Rf⁺
• Genetic Background: involves: 129/RrSv

limbs/digits/tail

kinked tail ( J:278 )

• 69% of mice examined had kinked tails and fused ribs

skeleton

abnormal rib development ( J:278 )

• sporadic fusions of rib anlagen can be seen in E12 mutant mice

rib fusion ( J:278 )

• fused ribs are the most frequent abnormality seen in mutant mice

• 69% of mice examined had fused ribs and kinked tails

abnormal vertebral column morphology ( J:278 )

• thoracic curvature is often seen

abnormal vertebral arch morphology ( J:278 )

• 30 of mutant mice show some abnormality as they age

fusion of vertebral arches ( J:278 )

• fusion of adjacent neural arches is often seen

abnormal vertebral body morphology ( J:278 )

• displaced vertebral bodies are observed in 36% of mice analyzed

fusion of vertebral bodies ( J:278 )

• fusion of adjacent centra is seen in 2% of mice

hemivertebra ( J:278 )

• seen in about 2% of mice

reproductive system

female infertility ( J:278 )

• 55% of females with kinked tails were infertile