All Phenotypes Eh MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eh/Eh	B6By.Cg-Eh/J	MGI:3720671
ht2	Eh/Eh⁺	B6By.Cg-Eh/J	MGI:3720672
ht3	Eh/Eh⁺	Not Specified	MGI:3027523

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cleft palate in the Eh/Eh neonate

mortality/aging

neonatal lethality, complete penetrance ( J:121991 )

• die within 24 hours after birth

respiratory system

respiratory distress ( J:121991 )

• newborns exhibit gasping respiration

homeostasis/metabolism

cyanosis ( J:121991 )

• newborns exhibit progressive cyanosis

craniofacial

palatal shelves fail to meet at midline ( J:121991 )

• at E15.5, palatal shelves of the mutant embryos show impaired horizontal growth and fail to make contact and fuse

• no defects are seen in cell proliferation or apoptosis in the palate

cleft secondary palate ( J:121991 )

• mice show a complete cleft of the secondary palate

digestive/alimentary system

palatal shelves fail to meet at midline ( J:121991 )

• at E15.5, palatal shelves of the mutant embryos show impaired horizontal growth and fail to make contact and fuse

• no defects are seen in cell proliferation or apoptosis in the palate

cleft secondary palate ( J:121991 )

• mice show a complete cleft of the secondary palate

meteorism ( J:121991 )

• gastrointestinal tracts of mutant mice are often filled with air

hearing/vestibular/ear

abnormal tympanic ring morphology ( J:121991 )

• tympanic rings are shortened and deformed in neonates

growth/size/body

palatal shelves fail to meet at midline ( J:121991 )

• at E15.5, palatal shelves of the mutant embryos show impaired horizontal growth and fail to make contact and fuse

• no defects are seen in cell proliferation or apoptosis in the palate

cleft secondary palate ( J:121991 )

• mice show a complete cleft of the secondary palate

meteorism ( J:121991 )

• gastrointestinal tracts of mutant mice are often filled with air

behavior/neurological

absent gastric milk in neonates ( J:121991 )

Allelic Composition	Eh/Eh⁺
Genetic Background	B6By.Cg-Eh/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eh mutation (1 available); any Eh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal tympanic ring morphology ( J:121991 )

• tympanic rings are shortened

Allelic Composition	Eh/Eh⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eh mutation (1 available); any Eh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hairy ears ( J:30359 )

• unusually long hair at the base of the ears

• suggests an extended anagen stage of hair development at this location

small ears ( J:13437 , J:14236 )

craniofacial

hairy ears ( J:30359 )

• unusually long hair at the base of the ears

• suggests an extended anagen stage of hair development at this location

small ears ( J:13437 , J:14236 )

integument

ectopic hair growth ( J:13437 , J:14236 )

• tufts of hair on inner ear (J:13437)

excessive hair ( J:13437 )

hairy ears ( J:30359 )

• unusually long hair at the base of the ears

• suggests an extended anagen stage of hair development at this location

growth/size/body

hairy ears ( J:30359 )

• unusually long hair at the base of the ears

• suggests an extended anagen stage of hair development at this location

small ears ( J:13437 , J:14236 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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