All Phenotypes H19<tm1Lda> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H19^tm1Lda
targeted mutation 1, Luisa Dandolo
MGI:1860792

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H19^tm1Lda/H19^tm1Lda	involves: 129S2/SvPas	MGI:3845807
hm2	H19^tm1Lda/H19^tm1Lda	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:3845816
ht3	H19^tm1Lda/H19⁺	involves: 129S2/SvPas	MGI:3845808
cx4	Apc^tm1Cip/Apc⁺ H19^tm1Lda/H19⁺	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3845818
cx5	Apc^tm1Cip/Apc⁺ H19^tm1Lda/H19⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA	MGI:3845817

Allelic Composition	H19^tm1Lda/H19^tm1Lda
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19^tm1Lda mutation (1 available); any H19 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:41236 )

• mice are 8% heavier than normal

Allelic Composition	H19^tm1Lda/H19^tm1Lda
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19^tm1Lda mutation (1 available); any H19 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:138826 )

• teratocarcinomas derived from E6.5 embryos grafted into wild-type mice grow 1.6-fold more than wild-type-derived tumors

• teratocarcinomas derived from E6.5 embryos grafted into Igf2^tm1Rob homozygotes grow 2-fold more than wild-type-derived tumors

Allelic Composition	H19^tm1Lda/H19⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19^tm1Lda mutation (1 available); any H19 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:41236 )

• mice are 8% heavier than normal when this allele is inherited maternally

Allelic Composition	Apc^tm1Cip/Apc⁺ H19^tm1Lda/H19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Cip mutation (0 available); any Apc mutation (154 available)
H19^tm1Lda mutation (1 available); any H19 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased adenoma incidence ( J:138826 )

• mice exhibit a 1.4-fold increase in the number of adenomas compared to in Apc^tm1Cip heterozygotes

Allelic Composition	Apc^tm1Cip/Apc⁺ H19^tm1Lda/H19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenocarcinoma incidence ( J:138826 )

• some adenocarcinoma in situ in the intestines

increased adenoma incidence ( J:138826 )

• mice exhibit a 2.2-fold increase in the number of adenomas compared to in Apc^tm1Cip heterozygotes

digestive/alimentary system

colon polyps ( J:138826 )

• mice exhibit a 3-fold increase in the number of small polyps compared to in Apc^tm1Cip heterozygotes

increased intestinal adenocarcinoma incidence ( J:138826 )

• some adenocarcinoma in situ in the intestines

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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