Phenotypes associated with this allele

• Allele Symbol: Jsr
• Allele Name: jumbled spine and ribs
• Allele ID: MGI:1859954
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jsr/Jsr	CKH.CTA-Jsr	MGI:3707416
ht2	Jsr/Jsr^+	CKH.CTA-Jsr	MGI:3707415
ht3	Jsr/Jsr^+	involves: CTA/Idr * KYF/MsIdr	MGI:3707413

Genotype
MGI:3707416

hm1

• Allelic Composition: Jsr/Jsr
• Genetic Background: CKH.CTA-Jsr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

+/+ and Jsr/Jsr histological sections of E13.0 embryos.

skeleton

rib fusion ( J:53810 )

• several ribs are fused at the proximal region because of fusion of thoracic vertebrae

thoracic vertebral fusion ( J:53810 )

• fusion of thoracic vertebrae results in the fusion of several ribs at the proximal region

abnormal vertebrae development ( J:53810 )

• cartilaginous aggregations of primordial vertebrae are disarranged

• segmentations of vertebrae at the caudal part of the embryos are unclear and decreased in number compared with wild-type

abnormal vertebral arch development ( J:53810 )

• neural arches surrounding the spinal cord are irregularly developed

short vertebral column ( J:53810 )

• the length of the skeletal axis is shortened

reproductive system

reduced fertility ( J:53810 )

• efficiency of reproduction is extremely decreased

Genotype
MGI:3707415

ht2

• Allelic Composition: Jsr/Jsr⁺
• Genetic Background: CKH.CTA-Jsr

Skeletons of 8 week old +/+ and Jsr/+ mice

growth/size/body

decreased body length ( J:53810 )

• short trunk

limbs/digits/tail

small caudal vertebrae ( J:53810 )

• the caudal vertebral bones, in particular, are extremely smaller

short tail ( J:53810 )

kinked tail ( J:53810 )

skeleton

rib fusion ( J:53810 )

• several ribs are fused at the proximal region because of fusion of thoracic vertebrae

scoliosis ( J:53810 )

• spine often shows scoliosis

abnormal vertebrae morphology ( J:53810 )

• vertebrae are irregularly fragmented

small caudal vertebrae ( J:53810 )

• the caudal vertebral bones, in particular, are extremely smaller

abnormal vertebrae development ( J:53810 )

• cartilaginous aggregations of primordial vertebrae are disarranged

• segmentations of vertebrae at the caudal part of the embryos are unclear and decreased in number compared with wild-type

abnormal vertebral arch development ( J:53810 )

• neural arches surrounding the spinal cord are irregularly developed

small vertebrae ( J:53810 )

• vertebrae are shorter than in wild-type

vertebral fusion ( J:53810 )

• vertebrae are fused

thoracic vertebral fusion ( J:53810 )

• fusion of thoracic vertebrae results in the fusion of several ribs at the proximal region

short vertebral column ( J:53810 )

• the length of the skeletal axis is shortened

Genotype
MGI:3707413

ht3

• Allelic Composition: Jsr/Jsr⁺
• Genetic Background: involves: CTA/Idr * KYF/MsIdr

skeleton

rib fusion ( J:12974 )

• often as many as 2 to 4 ribs are abnormally fused together with large spaces between groups

kyphosis ( J:12974 )

lordosis ( J:12974 )

scoliosis ( J:12974 )

abnormal vertebrae morphology ( J:12974 )

• vertebral elements are abnormally formed and irregularly fragmented

decreased vertebrae number ( J:12974 )

• vertebral elements are reduced in number

vertebral fusion ( J:12974 )

• vertebral elements are fused with each other