Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rfo mutation
(0 available);
any
Apc mutation
(154 available)
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mortality/aging
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• fewer than the expected numbers of homozygotes are observed at weaning on the congenic C57BL/6J background, however no postnatal lethality is seen on a mixed 129P2/OlaHsd and C57BL/6J background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rfo mutation
(0 available);
any
Apc mutation
(154 available)
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cellular
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N |
• no obvious microtubule abnormalities in MEFs in a wound healing assay
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Allelic
Composition |
Apctm1Rfo/Apctm1Rfo
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rfo mutation
(0 available);
any
Apc mutation
(154 available)
|
|
|
mortality/aging
|
N |
• Background Sensitivity: unlike on a congenic C57BL/6J backround where mutants exhibit postnatal lethality, the expected numbers of homozygotes are observed on a mixed 129P2/OlaHsd and C57BL/6J background
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endocrine/exocrine glands
growth/size/body
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• always in proximity of the nipple, most males develop 1-3 cutaneous cysts ranging in size from 1-3 mm
• cysts are hybrid infundibular/matrical cysts lined by orthokeratinizing sqamous epithelium and stretches of matrix cells
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• due to growth retardation
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• 20% growth retardation is apparent by 10 days of age
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reproductive system
renal/urinary system
neoplasm
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N |
• mutants are tumor-free unlike most other Apc mutants
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integument
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• always in proximity of the nipple, most males develop 1-3 cutaneous cysts ranging in size from 1-3 mm
• cysts are hybrid infundibular/matrical cysts lined by orthokeratinizing sqamous epithelium and stretches of matrix cells
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Analysis Tools