Phenotypes associated with this allele

• Allele Symbol: Msh3^tm1Rak
• Allele Name: targeted mutation 1, Raju Kucherlapati
• Allele ID: MGI:1858056
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msh3^tm1Rak/Msh3^tm1Rak	involves: 129/Sv * C57BL/6J * SJL	MGI:3851215
cx2	Msh3^tm1Rak/Msh3^tm1Rak Msh6^tm1Rak/Msh6^tm1Rak	involves: 129/Sv * C57BL/6J * SJL	MGI:2183371

Genotype
MGI:3851215

hm1

• Allelic Composition: Msh3^tm1Rak/Msh3^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:60604 )

N • mice exhibit normal life span

neoplasm

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 4 of 39 mice unlike in wild-type mice

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 4 of 39 mice unlike in wild-type mice

cellular

impaired mismatch repair ( J:60604 )

• mismatch repair is partially defective

homeostasis/metabolism

impaired mismatch repair ( J:60604 )

• mismatch repair is partially defective

Genotype
MGI:2183371

cx2

• Allelic Composition: Msh3^tm1Rak/Msh3^tm1Rak; Msh6^tm1Rak/Msh6^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

mortality/aging

premature death ( J:60604 )

• 50% moribund or morbid by 5 - 6 months of age

neoplasm

increased gastrointestinal tumor incidence ( J:60604 )

• mice develop predominantly GI tumors

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 12 of 16 mice

increased lymphoma incidence ( J:60604 )

• non-Hodgkin's lymphomas

cellular

impaired mismatch repair ( J:60604 )

• cells lack mismatch repair

homeostasis/metabolism

impaired mismatch repair ( J:60604 )

• cells lack mismatch repair

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:60604 )

• mice develop predominantly GI tumors

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 12 of 16 mice