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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mitfmi-tg
microphthalmia transgene insertion
MGI:1858053
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mitfmi-tg/Mitfmi-tg B6.Cg-Mitfmi-tg MGI:4356509
hm2
 		Mitfmi-tg/Mitfmi-tg involves: C3H/HeNCrl * C57BL/6NCrl MGI:4356490
ht3
 		Mitfmi-tg/Mitf+ involves: C3H/HeNCrl * C57BL/6NCrl MGI:4356491


Genotype
MGI:4356509
hm1
Allelic
Composition		 Mitfmi-tg/Mitfmi-tg
Genetic
Background		 B6.Cg-Mitfmi-tg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-tg mutation (0 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:53161 )
• serotonin concentrations in cultured mast cells are lower than in wild-type cells but not as low as in MitfMi cultured mast cells
• however, mast cells exhibit normal cytotoxicity towards YAC-1 cells

pigmentation
absent coat pigmentation ( J:53161 )
• mice are white

homeostasis/metabolism
decreased serotonin level ( J:53161 )
• serotonin concentrations in cultured mast cells are lower than in wild-type cells but not as low as in MitfMi cultured mast cells

integument
absent coat pigmentation ( J:53161 )
• mice are white

hematopoietic system
abnormal mast cell physiology ( J:53161 )
• serotonin concentrations in cultured mast cells are lower than in wild-type cells but not as low as in MitfMi cultured mast cells
• however, mast cells exhibit normal cytotoxicity towards YAC-1 cells




Genotype
MGI:4356490
hm2
Allelic
Composition		 Mitfmi-tg/Mitfmi-tg
Genetic
Background		 involves: C3H/HeNCrl * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-tg mutation (0 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal iris pigmentation ( J:16790 )
• the iris is minimally pigmented unlike in wild-type mice
• iris melanocytes frequently cluster, are more floccular, and exhibit incomplete in pigment deposition unlike wild-type melanocytes
ciliary body hypoplasia ( J:16790 )
• extremely underdeveloped
iris hypoplasia ( J:16790 )
• the iris is underdeveloped

pigmentation
absent coat pigmentation ( J:15418 )
• mice are white
abnormal iris pigmentation ( J:16790 )
• the iris is minimally pigmented unlike in wild-type mice
• iris melanocytes frequently cluster, are more floccular, and exhibit incomplete in pigment deposition unlike wild-type melanocytes
abnormal melanocyte morphology ( J:15418 )
• melanocyte cultures from the skin produce fewer than 10% initial melanocyte colonies that are non-proliferating unlike wild-type cultures

integument
absent coat pigmentation ( J:15418 )
• mice are white




Genotype
MGI:4356491
ht3
Allelic
Composition		 Mitfmi-tg/Mitf+
Genetic
Background		 involves: C3H/HeNCrl * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-tg mutation (0 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanocyte morphology ( J:15418 )
• melanocyte cultures from the skin produces fewer melanocytes than wild-type cultures and melanocytes exhibit aberrant morphology




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory