Phenotypes associated with this allele

• Allele Symbol: Scd1^ab
• Allele Name: asebia
• Allele ID: MGI:1858028
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scd1^ab/Scd1^ab	involves: BALB/cCrglGa	MGI:3603115

Genotype
MGI:3603115

hm1

• Allelic Composition: Scd1^ab/Scd1^ab
• Genetic Background: involves: BALB/cCrglGa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

photophobia ( J:30359 )

• mutants are photophobic

blindness ( J:13143 )

• coincident with ageing

• scratching increases in older animals but is limited to the eyes resulting in inflammation

growth/size/body

postnatal growth retardation ( J:13143 )

• mutants are retarded in growth throughout life

• growth is most retarded when young are born to mutant mothers

reproductive system

abnormal reproductive system physiology ( J:13143 )

abnormal estrous cycle ( J:13143 )

♀

prolonged diestrus ( J:13143 )

♀ • mutant females have longer than normal diestrous periods

♀ • length of diestrous correlates with degree females are affected with hyperkeratosis and alopecia

reduced female fertility ( J:13143 )

♀

endocrine/exocrine glands

sebaceous gland hypoplasia ( J:30359 )

• glands are hypoplastic, budlike in appearance

• glands lack orderly maturation of peripheral reserve cells into vacuolated holocrine cells

integument

sebaceous gland hypoplasia ( J:30359 )

• glands are hypoplastic, budlike in appearance

• glands lack orderly maturation of peripheral reserve cells into vacuolated holocrine cells

abnormal hair growth ( J:13143 )

alopecia ( J:13143 )

• impaired growth of coat can be recognized as early as 7 days of age

• with age hair becomes increasingly sparse and loose, fine scales appear

abnormal hair follicle morphology ( J:30780 )

abnormal hair follicle development ( J:13143 )

• base of the follicle sometimes shows excessive development

• many follicles are plugged with keratotic material

abnormal hair follicle inner root sheath morphology ( J:30780 )

• inner root sheath plugs hair canal, adhering to emerging hair

abnormal piliary canal morphology ( J:30780 )

• keratinized material forming plugs within the hair canals

decreased hair follicle number ( J:13143 )

• follicles extend deep into fat tissue as single units rather than multiple units

abnormal skin morphology ( J:13143 , J:31038 )

• reciprocal skin transplants suggest normal skin has a diffuseable substance that can partially alleviate the symptoms (J:13143)

• cellular layers of the skin are hyperplastic from birth, increasing markedly with age (J:31038)

abnormal cutaneous collagen fibril morphology ( J:31038 )

abnormal cutaneous elastic fiber morphology ( J:31038 )

abnormal dermal layer morphology ( J:31038 )

• fibroblasts of the dermis are abnormal

hyperkeratosis ( J:13143 )

abnormal skin physiology ( J:5013 )

• skin is deficient in esterified sterols and waxes

• skin is rich in free sterols

behavior/neurological

photophobia ( J:30359 )

• mutants are photophobic

homeostasis/metabolism

photophobia ( J:30359 )

• mutants are photophobic

abnormal metabolism ( J:30359 )

• mice have a distinct odor