Phenotypes associated with this allele

• Allele Symbol: Grm6^tm1Nak
• Allele Name: targeted mutation 1, Shigetada Nakanishi
• Allele ID: MGI:1857985
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm6^tm1Nak/Grm6^tm1Nak	involves: 129S/SvEv	MGI:5440451
hm2	Grm6^tm1Nak/Grm6^tm1Nak	involves: 129S/SvEv * C57BL/6 * DBA	MGI:2176770

Genotype
MGI:5440451

hm1

• Allelic Composition: Grm6^tm1Nak/Grm6^tm1Nak
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye electrophysiology ( J:187720 )

• in an electroretinogram, the a wave stays at a plateau level for ~200 ms before returning to the baseline and the b wave is absent

Genotype
MGI:2176770

hm2

• Allelic Composition: Grm6^tm1Nak/Grm6^tm1Nak
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

vision/eye

abnormal eye electrophysiology ( J:48532 )

• electroretinogram shows that the b-wave is fully abolished under both dark- or light-adapted conditions, indicating impaired synaptic transmission in ON bipolar cells, however retinal organization and projection of optic fibers to the brain are normal

nervous system

abnormal synaptic transmission ( J:48532 )

• impairment of synaptic transmission in ON bipolar cells of the retina and absent ON response, but not OFF response, in the superior colliculus

behavior/neurological

behavior/neurological phenotype ( J:48532 )

N • no difference in avoidance learning acqusition in response to light exposure between wild-type and mutants