All Phenotypes Lbp<tm1Buru> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lbp^tm1Buru/Lbp^tm1Buru	B6.129-Lbp^tm1Buru	MGI:4358282
hm2	Lbp^tm1Buru/Lbp^tm1Buru	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:4358244
hm3	Lbp^tm1Buru/Lbp^tm1Buru	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4358229

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal chemokine level ( J:129411 )

• mice have lower secretion of keratinocyte chemokine (CXCL1) in the airway after 1 ng dose of LPS

• mice have higher secretion of CXCL1 in the airway after 100 ng dose of LPS compared to LPS-treated controls

abnormal tumor necrosis factor secretion ( J:129411 )

• there is less secretion of TNF in the airway after 1 ng dose of LPS compared to LPS-treated controls

abnormal acute inflammation ( J:129411 )

• mice are resistant to airway sensitivity induced by low intranasal doses of LPS but have augmented inflammatory responses to high doses of LPS

• mice have lower neutrophil influx and secretion of TNF and keratinocyte chemokine in the airway after 1ng dose of LPS

• mice have enhanced neutrophil influx and cytokine secretion after a 100ng LPS dose compared to controls

• histological scoring confirms more severe inflammation in the lungs 6 and 22 hours after 100 ng LPS administration

abnormal innate immunity ( J:129411 )

• mice are resistant to airway sensitivity induced by low intranasal doses of LPS but have augmented inflammatory responses to high doses of LPS

abnormal neutrophil physiology ( J:129411 )

• mice have lower neutrophil influx into the airways with 1ng dose of LPS but higher neutrophil influx with 100ng doses of LPS

homeostasis/metabolism

abnormal chemokine level ( J:129411 )

• mice have lower secretion of keratinocyte chemokine (CXCL1) in the airway after 1 ng dose of LPS

• mice have higher secretion of CXCL1 in the airway after 100 ng dose of LPS compared to LPS-treated controls

hematopoietic system

abnormal neutrophil physiology ( J:129411 )

• mice have lower neutrophil influx into the airways with 1ng dose of LPS but higher neutrophil influx with 100ng doses of LPS

Allelic Composition	Lbp^tm1Buru/Lbp^tm1Buru
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbp^tm1Buru mutation (0 available); any Lbp mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:67090 )

• OVA-sensitized mice do not develop significant airway reactivity following beta-methylcholine challenge

• lung inflammation after methylcholine challenge is different with decreased mucin production and some inflammatory loci shifted to airway regions

• nitrous oxide is not produced in the challenged lungs as occurs in wild-type controls

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:67090 )

• OVA-sensitized mice do not produce nitrous oxide in the lungs in response to airway challenge as occurs in wild-type controls

Allelic Composition	Lbp^tm1Buru/Lbp^tm1Buru
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbp^tm1Buru mutation (0 available); any Lbp mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune serum protein physiology ( J:44878 )

• lipopolysaccharide-binding protein is absent from the blood

decreased tumor necrosis factor secretion ( J:44878 )

• whole blood produces little TNF in response to ex vivo exposure to LPS

• little TNF response to LPS also occurs when mutant plasma is added to wild-type blood cells

• no differences are seen when LPS is administered in vivo

homeostasis/metabolism

abnormal blood homeostasis ( J:44878 )

• whole blood produces little TNF in response to ex vivo exposure to LPS

• little TNF response to LPS also occurs when mutant plasma is added to wild-type blood cells

• no differences are seen when LPS is administered in vivo

decreased susceptibility to injury ( J:126676 )

• mice are resistant to liver injury caused by 4 weeks of ethanol administration

• increases in liver-to-body weight ratio are decreased by almost 20%

• serum transaminase levels are about two-thirds less than ethanol fed controls

liver/biliary system

abnormal liver physiology ( J:126676 )

• mice are resistant to hepatitis caused by long term ethanol feeding

• effects of 4-week ethanol feeding are blunted as measured by several parameters

• increases in liver-to-body weight ratio are decreased by almost 20%

• serum transaminase levels are about two-thirds less than ethanol fed controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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