Analysis Tools
mortality/aging
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• die between E3.5 and E5.5
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reproductive system
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Allele Symbol Allele Name Allele ID |
Cdx2tm1Fbe targeted mutation 1, F Beck MGI:1857928 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between E3.5 and E5.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes die around implantation
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• a 3-fold increase in cell death is seen in the inner cell mass at E4.5
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• an 8-fold increase in cell death is seen in the trophoectoderm at E4.5
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• at E4.5 embryos are still in the zona pellucida
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• at E4.5, little or no blastocoelic cavity is seen
• the blastocoel is initially formed but collapses
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• after 72 hours in culture (starting at the 8-cell stage) trophoectodermal cells appear rounded and non-epithelial
• tight and adherens junctions appear abnormal at the late blastocyst stage and it appears that the polarity and integrity of the trophoectoderm are not maintained
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• trophoblast giant cells are not formed and trophoblast stem cell lines can not be established
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• trophoblast differentiation is impaired beyond the expanded blastocyst stage
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• a 3-fold increase in cell death is seen in the inner cell mass at E4.5
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• an 8-fold increase in cell death is seen in the trophoectoderm at E4.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 6 of 62 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5
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• allantois of 3 of 54 heterozygotes has not fused with the chorion at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• anterior homeotic shift of the cervical and thoracic spine such as an 8th rib attached to the sternum, or the second rib attached to the sternum at the top of the manubrium together with the first rib
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• T3 shows morphological features characteristic of the immediately cranial vertebrae in the wild-type
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• C6 and C7 show morphological features characteristic of the immediately cranial vertebrae in the wild-type
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• 50-60% exhibit a short or kinked tail
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• 50-60% exhibit a short or kinked tail
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• presence of multiple adenomatous polyps at 12-28 weeks of age
• tumors are found predominately in the proximal colon and occasionally in the small intestine
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• tumors are found predominately in the proximal colon
• largest tumors are pedunculated tubulovillous colonic adenomata
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• presence of multiple adenomatous polyps at 12-28 weeks of age
• tumors are found predominately in the proximal colon and occasionally in the small intestine
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• tumors are found predominately in the proximal colon
• largest tumors are pedunculated tubulovillous colonic adenomata
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reach the blastocyst stage then collapse around implantation
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• reach the blastocyst stage then collapse around implantation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reach the blastocyst stage then collapse around implantation
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• reach the blastocyst stage then collapse around implantation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2 of 11 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5
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• allantois of 2 of 28 mutants has not fused with the chorion at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die shortly after E10.5
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• exhibit developmental retardation at E10.5
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• truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud
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• exhibit developmental retardation at E10.5
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• allantoic endothelial cells often exhibit, to a variable extent, a poorer degree of primary vessel organization around the time of chorioallantoic fusion
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• at E10.5, maternal blood pools and embryonic blood vessels are widely separated
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• the hemotrichorial membrane is almost completely absent
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• all embryos that do undergo chorioallantoic fusion display deficient placental labyrinth development at E10.5
• fail to properly extend the allantoic vascular network into the chorionic ectoderm and do not develop a functional placental labyrinth
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• allantois of 7 of 35 mutants has not fused with the chorion at E9.5
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• have 14 ribs due to the partial or complete bilateral rib attachment to V21
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• 4 of 4 have the 8th pair of ribs attached to the sternum, indicating anterior transformation at the level of V15
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• 4 of 4 have a partial or complete rib attached to V21 bilaterally, at the position normally corresponding to the first lumbar vertebrae
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• truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud
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• at E10.5, maternal blood pools and embryonic blood vessels are widely separated
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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