Phenotypes associated with this allele

• Allele Symbol: Mst1r^Fv2-s
• Allele Name: Friend virus susceptibility 2
• Allele ID: MGI:1857882
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mst1r^Fv2-s/Mst1r^Fv2-s	B6.DDD-Mst1r^Fv2-s	MGI:5009032
hm2	Mst1r^Fv2-s/Mst1r^Fv2-s	C3H/Crgl	MGI:5009541
hm3	Mst1r^Fv2-s/Mst1r^Fv2-s	either: A/Crgl or C57BL/Crgl	MGI:5009040
hm4	Mst1r^Fv2-s/Mst1r^Fv2-s	either: BALB/cCrgl or DBA/2Crgl or Swiss	MGI:5009042

Genotype
MGI:5009032

hm1

• Allelic Composition: Mst1r^Fv2-s/Mst1r^Fv2-s
• Genetic Background: B6.DDD-Mst1r^Fv2-s

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:5120 )

• Background Sensitivity: early splenomegaly occurs in this normally viral resistant B6 background

increased susceptibility to Retroviridae infection ( J:5120 )

• Background Sensitivity: the effect of Mst1r^Fv2-s on mouse Friend leukemia viral infection as expressed by susceptible strains was not modified by the B6 background

hematopoietic system

enlarged spleen ( J:5120 )

• Background Sensitivity: early splenomegaly occurs in this normally viral resistant B6 background

growth/size/body

enlarged spleen ( J:5120 )

• Background Sensitivity: early splenomegaly occurs in this normally viral resistant B6 background

Genotype
MGI:5009541

hm2

• Allelic Composition: Mst1r^Fv2-s/Mst1r^Fv2-s
• Genetic Background: C3H/Crgl

immune system

increased susceptibility to Retroviridae infection ( J:167666 )

• by 28 days after ip injection of 0.5 ml of a 20% suspension of Friend virus 58% of mice showed evidence of infection

• degree of susceptibility is compared with host strains A/Crgl and C57BL/Crgl that showed no viral disease

Genotype
MGI:5009040

hm3

• Allelic Composition: Mst1r^Fv2-s/Mst1r^Fv2-s
• Genetic Background: either: A/Crgl or C57BL/Crgl

immune system

decreased susceptibility to Retroviridae infection ( J:167666 )

• 28 days after ip injection of 0.5 ml of a 20% suspension of Friend virus there was no overt or histological evidence of virus multiplication in the spleen

Genotype
MGI:5009042

hm4

• Allelic Composition: Mst1r^Fv2-s/Mst1r^Fv2-s
• Genetic Background: either: BALB/cCrgl or DBA/2Crgl or Swiss

immune system

enlarged spleen ( J:167666 )

• by 28 days after ip injection of 0.5 ml of a 20% suspension of Friend virus, splenomegaly was observed in all strains although more marked and regular in BALB/c

• degree of susceptibility is compared with host strains A/Crgl and C57BL/Crgl that showed no viral disease

increased susceptibility to Retroviridae infection ( J:167666 )

• all strains are equally and maximally susceptible, 96-100% showing infection at least by 28 days after ip injection of 0.5 ml of a 20% suspension of Friend virus

• degree of infection is compared with strains A and C57BL which failed to show any viral growth

hematopoietic system

enlarged spleen ( J:167666 )

• by 28 days after ip injection of 0.5 ml of a 20% suspension of Friend virus, splenomegaly was observed in all strains although more marked and regular in BALB/c

• degree of susceptibility is compared with host strains A/Crgl and C57BL/Crgl that showed no viral disease

growth/size/body

enlarged spleen ( J:167666 )

• by 28 days after ip injection of 0.5 ml of a 20% suspension of Friend virus, splenomegaly was observed in all strains although more marked and regular in BALB/c

• degree of susceptibility is compared with host strains A/Crgl and C57BL/Crgl that showed no viral disease