Phenotypes associated with this allele

• Allele Symbol: Mgat3^tm1Pst
• Allele Name: targeted mutation 1, Pamela Stanley
• Allele ID: MGI:1857829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgat3^tm1Pst/Mgat3^tm1Pst	involves: 129/Sv * C57BL/6 * CD-1 * SJL	MGI:4353907

Genotype
MGI:4353907

hm1

• Allelic Composition: Mgat3^tm1Pst/Mgat3^tm1Pst
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:48441 , J:86643 )

• at 7 months, 50% of mice treated with DEN and PB have 1 o 4 small liver tumors compared to 50 tumors per liver in similarly treated wild-type mice (J:48441)

• mice treated with DEN alone do not develop liver tumors unlike similarly treated wild-type and heterozygous mice (J:48441)

• mice treated with DEN have 50% fewer tumors than similarly treated wild-type or heterozygous mice (J:86643)

• after 4 months, DEN-treated mice develop less severe liver tumors than similarly treated wild-type mice (J:86643)

• at 5 and 6 months, DEN-treated mice develop fewer large liver tumors than in similarly treated wild-type mice (J:86643)

liver/biliary system

decreased hepatocyte proliferation ( J:86643 )

• following partial hepatectomy

decreased liver weight ( J:86643 )

• at 6 months, liver weight in DEN-treated mice is less than in similarly treated wild-type mice

impaired liver regeneration ( J:86643 )

• retarded

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:48441 , J:86643 )

• at 7 months, 50% of mice treated with DEN and PB have 1 o 4 small liver tumors compared to 50 tumors per liver in similarly treated wild-type mice (J:48441)

• mice treated with DEN alone do not develop liver tumors unlike similarly treated wild-type and heterozygous mice (J:48441)

• mice treated with DEN have 50% fewer tumors than similarly treated wild-type or heterozygous mice (J:86643)

• after 4 months, DEN-treated mice develop less severe liver tumors than similarly treated wild-type mice (J:86643)

• at 5 and 6 months, DEN-treated mice develop fewer large liver tumors than in similarly treated wild-type mice (J:86643)

cellular

decreased hepatocyte proliferation ( J:86643 )

• following partial hepatectomy