All Phenotypes Hoxa1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa1⁺
wild type
MGI:1857825

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxa1^tm1Mrc/Hoxa1⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2177820
cx2	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3043810
cx3	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3043811
cx4	Hoxa1^tm5Mrc/Hoxa1⁺ Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703018

Allelic Composition	Hoxa1^tm1Mrc/Hoxa1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm1Mrc mutation (0 available); any Hoxa1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:58093 )

• no obvious phenotype

Allelic Composition	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm2Mrc mutation (0 available); any Hoxa1 mutation (15 available)
Hoxa2^tm1Mrc mutation (0 available); any Hoxa2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:58093 )

• die shortly after birth of dehydration

behavior/neurological

abnormal suckling behavior ( J:58093 )

• unable to suckle

craniofacial

cleft secondary palate ( J:58093 )

• extent of cleft secondary palate not as great with decreased functional Hoxa1

digestive/alimentary system

cleft secondary palate ( J:58093 )

• extent of cleft secondary palate not as great with decreased functional Hoxa1

growth/size/body

cleft secondary palate ( J:58093 )

• extent of cleft secondary palate not as great with decreased functional Hoxa1

Allelic Composition	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:58093 )

• viable and fertile

Allelic Composition	Hoxa1^tm5Mrc/Hoxa1⁺ Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm5Mrc mutation (0 available); any Hoxa1 mutation (15 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• 17% of mice have a noticeably narrower range of whisker movements on one side

• 8% have a mutant-like eyelid closure reflex in one eye

paralysis ( J:119279 )

• some facial motor hypomorphism is observed; Hoxa1 haploinsufficiency is observed

nervous system

small facial motor nucleus ( J:119279 )

• haploinsufficient presumptive facial nuclei are smaller, rounder, and located more internally than wild-type

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve in affected mutants are thinner and sometimes atypically formed, but rarely missing

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