Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation
(0 available);
any
Rbl1 mutation
(60 available)
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mortality/aging
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• 70% of mice die by 3 weeks of age
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adipose tissue
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• in testicular and ovarian white adipose tissue fat pad
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• in white adipose tissue fat pad
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• in white adipose tissue fat pad
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• interscapular, inguinal, testicular, ovarian, and intraperitoneal white adipose fat pads are reduced in weight compared to in wild-type mice
• however, interscapular brown adipose tissue depots are normal
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• white adipose tissue resembles brown adipose tissue with small-sized, unilocular adipocytes with many multilocular appearing cells unlike in wild-type mice
• white adipose tissue differentiation of preadipocytes is deficient in vivo
• however, in vitro preadipocyte differentiation is normal
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• neonates and adults exhibit decreased white adipose tissue mass compared to in wild-type mice despite normal suckling, food intake, and nutrient absorption
• mice lack white adipose tissue in the interscapular and inguinal depots and have smaller than normal testicular and ovarian depots
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growth/size/body
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• at P5, mice are runted despite normal suckling
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liver/biliary system
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• at P5, the liver is yellow in appearance due to excessive lipid accumulation unlike in wild-type mice
• however, after weaning liver lipid content is normal
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation
(0 available);
any
Rbl1 mutation
(60 available)
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nervous system
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• mice exhibit an increase in the rate of progenitor regeneration
• however, neurogenesis in the olfactory bulb is normal
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• more proliferating cells are found in the ventricular subependyma than in wild-type mice
• the number of apoptotic cells in the ventricular subependyma is increased compared to in wild-type mice
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• mice exhibit increased neuronal precursor numbers due to increased proliferation
• cultured E10 telencephalic neuroepithelia produces more primary neurospheres than cultures from wild-type mice
• adult brain cultures produce 2-fold more primary neurospheres than cultures from wild-type mice independent of cell density
• mice exhibit a higher number of slowly dividing neural precursor cells compared to in wild-type mice
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cellular
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• mice exhibit an increase in the rate of progenitor regeneration
• however, neurogenesis in the olfactory bulb is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation
(0 available);
any
Rbl1 mutation
(60 available)
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mortality/aging
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• between 2 and 4 months, 10% of mice die unlike wild-type mice
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hematopoietic system
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• sites of extramedullary hematopoiesis exhibit hyperplasia rather than neoplasia
• mice develop a diathetic myeloproliferative disorder
• the number of mice exhibiting abnormal hematopoiesis increases with age
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• the number of colony forming units of granulocyte-macrophages that form from femur marrow is increased 2.7- to 12-fold compared to in wild-type samples
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• extramedullary hematopoiesis is present in the spleen and liver with some mice exhibiting extramedullary hematopoiesis in the thymus, pancreas, kidneys, and skeletal muscles
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• with a strong shift to myeloid lineages
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• myeloid extramedullary hematopoiesis is present in the red pulp
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growth/size/body
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• all mice are runted
• Background Sensitivity: runting is more severe on a background involving 129S4/SvJae and BALB/cJ than on one involving 129S4/SvJae, BALB/cJ, and C57BL/6J
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• by 3 weeks of age mice weight half as much as wild-type mice
• by 12 weeks, mice weigh 80% of wild-type
• however, by 15 months mice have a normal weight
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• mice exhibit postnatal growth retardation
• however, mice exhibit normal postnatal development
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cellular
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• proliferation of adult myoblast in culture is increased compared to that of wild-type myoblasts with a shift from G1 to S phase and an 8-fold reduction in spontaneous differentiation
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• mouse embryonic fibroblasts from E13.5 embryos exhibit increased proliferation doubling every 35 hours compared with wild-type cells that double every 60 hours
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immune system
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• myeloid extramedullary hematopoiesis is present in the red pulp
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• at 10 months, 70% of mice exhibit evidence of acute or chronic inflammation unlike wild-type mice
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muscle
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• proliferation of adult myoblast is increased compared to that of wild-type myoblasts with a shift from G1 to S phase and an 8-fold reduction in spontaneous differentiation
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integument
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• skin ulcers and abscesses
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Allelic
Composition |
Rbl1tm1Mru/Rbl1tm1Mru
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Genetic
Background |
involves: 129S4/SvJae * BALB/cJ * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Mru mutation
(0 available);
any
Rbl1 mutation
(60 available)
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growth/size/body
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• Background Sensitivity: after 2 generations of crosses involving 129S4/SvJae, BALB/cJ, and C57BL/6J, fewer mice appear runted than on a background involving 129S4/SvJae and BALB/cJ
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation
(5 available);
any
Rb1 mutation
(106 available)
Rbl1tm1Mru mutation
(0 available);
any
Rbl1 mutation
(60 available)
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nervous system
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• mice exhibit increased neuronal precursor numbers due to increased proliferation
• cultured E10 telencephalic neuroepithelia produces more primary neurospheres than cultures from wild-type mice
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Analysis Tools