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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlx5+
wild type
MGI:1857791
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dlx5tm1(cre/ERT2)Zjh/Dlx5+ C57BL/6-Dlx5tm1(cre/ERT2)Zjh MGI:4355325
ht2
 		Dlx5tm1.1Levi/Dlx5+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3701345
ht3
 		Dlx5tm1Levi/Dlx5+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3701346
ht4
 		Dlx5tm1Jlr/Dlx5+ involves: 129X1/SvJ * C57BL/6J MGI:2169723
ht5
 		Dlx5tm1(cre/ERT2)Zjh/Dlx5+ involves: C57BL/6 * SJL MGI:4355391


Genotype
MGI:4355325
ht1
Allelic
Composition		 Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic
Background		 C57BL/6-Dlx5tm1(cre/ERT2)Zjh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5tm1(cre/ERT2)Zjh mutation (1 available); any Dlx5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:151755 )
• mice are viable and fertile




Genotype
MGI:3701345
ht2
Allelic
Composition		 Dlx5tm1.1Levi/Dlx5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5tm1.1Levi mutation (0 available); any Dlx5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:56557 )
• surprisingly, heterozygotes die before they reach sexual maturity at 18 days after birth, with no obvious defects or skeletal malformations




Genotype
MGI:3701346
ht3
Allelic
Composition		 Dlx5tm1Levi/Dlx5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5tm1Levi mutation (1 available); any Dlx5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:56557 )
• in contrast to Dlx5tm1.1Levi heterozygotes, these heterozygotes are viable and fertile and do not display any obvious abnormalities




Genotype
MGI:2169723
ht4
Allelic
Composition		 Dlx5tm1Jlr/Dlx5+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5tm1Jlr mutation (1 available); any Dlx5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal sexual interaction ( J:56559 )
• heterozygotes do not breed readily

nervous system
exencephaly ( J:56559 )
• ~3% of newborn heterozygotes display exencephaly
• Background Sensitivity: the frequency of exencephalic heterozygotes (~3%) is significantly reduced with further outbreeding to C57BL/6J




Genotype
MGI:4355391
ht5
Allelic
Composition		 Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5tm1(cre/ERT2)Zjh mutation (1 available); any Dlx5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:151755 )
• mice are viable and fertile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory