Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
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mortality/aging
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• no homozygous mutants born from crosses of heterozygotes
• development seemed normal through E7
• by E8.5 cell death could be observed in some areas
• resorption continuing at E9.5 when most organized structure disappeared
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embryo
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• the 3 germ layers fail to form
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• by E7.5 homozygotes were about half normal length
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• around E7.0 cells begin detaching from the embryonic ectoderm and disperse into the proamniotic cavity
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• extraembryonic cavities failed to form
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• allantois failed to form
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growth/size/body
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• by E7.5 homozygotes were about half normal length
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
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vision/eye
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• unilateral in some mice
• bilateral in some mice
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• unilateral in some mice
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nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Tg(Msx2-cre)5Rem mutation
(2 available)
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mortality/aging
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• mutant mice are live-born but die within 24 hrs of birth
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limbs/digits/tail
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• AER formation fails to initiate in the mutant hindlimbs whereas in the forelimbs, AER is properly initiated at 20 somites but eventually disappears in the anterior and posterior extremes by ~38 somites
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• mutant forelimbs are present but truncated at the level of the humerus or ulna
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• in newborn mutants, the humerus appears largely unaffected but shows absence of the deltoid crest
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• in mutant newborns, the proximal ulna is present to variable extents
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• all mutant pups completely lack hindlimbs
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skeleton
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• in newborn mutants, the humerus appears largely unaffected but shows absence of the deltoid crest
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• in mutant newborns, the proximal ulna is present to variable extents
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embryo
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• in mutant hindlimbs, where an AER never forms, extensive apoptosis occurs throughout the hindlimb mesenchyme and adjacent ectoderm at the 35-42 somite stage; elevated apoptosis in the mesenchyme is more significant dorsally
• in the forelimbs, however, where the AER disappears later in development, apoptosis is restricted to the distal mesenchyme and ectoderm
• no significant reduction of cell proliferation is observed in the mutant mesenchyme or ectoderm
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• AER formation fails to initiate in the mutant hindlimbs whereas in the forelimbs, AER is properly initiated at 20 somites but eventually disappears in the anterior and posterior extremes by ~38 somites
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behavior/neurological
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• newborn mutant mice fail to nurse
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cellular
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• in mutant hindlimbs, where an AER never forms, extensive apoptosis occurs throughout the hindlimb mesenchyme and adjacent ectoderm at the 35-42 somite stage; elevated apoptosis in the mesenchyme is more significant dorsally
• in the forelimbs, however, where the AER disappears later in development, apoptosis is restricted to the distal mesenchyme and ectoderm
• no significant reduction of cell proliferation is observed in the mutant mesenchyme or ectoderm
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation
(2 available)
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limbs/digits/tail
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• at E16.5, clear zones of hypertrophy are visible in limbs compared to controls
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skeleton
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• in mutant tibia, no Oc+ osteoblasts are detected, indicating failure of osteoblast progression to terminal osteoblasts
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• hypertrophic chondrocytes line the periosteal region in addition to the normal growth plate
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• membranous bone cranial ossification centers are absent at E18.5
• ossification in mutant periosteum of the tibia is absent
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• at E18.5, mutant limbs show absence of mineralized bone matrix compared to wild-type embryos and remaining mineralization is associated with hypertrophic chondrocytes; there appears to be complete loss of bone deposition
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cellular
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• in mutant tibia, no Oc+ osteoblasts are detected, indicating failure of osteoblast progression to terminal osteoblasts
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
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nervous system
vision/eye
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• bilateral in some mice
• unilateral in some mice
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• unilateral in some mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
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nervous system
vision/eye
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• bilateral in some mice
• unilateral in some mice
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• unilateral in some mice
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Analysis Tools