Phenotypes associated with this allele

• Allele Symbol: Hoxc4^tm1Hsu
• Allele Name: targeted mutation 1, Hirofumi Suemori
• Allele ID: MGI:1857570
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxc4^tm1Hsu/Hoxc4^tm1Hsu	involves: 129S/SvEv * A/J	MGI:3796846
ht2	Hoxc4^tm1Hsu/Hoxc4^+	involves: 129S/SvEv * A/J	MGI:3796845

Genotype
MGI:3796846

hm1

• Allelic Composition: Hoxc4^tm1Hsu/Hoxc4^tm1Hsu
• Genetic Background: involves: 129S/SvEv * A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:31635 )

N • cervical vertebrae anterior to C7 are not transformed

increased sternebra number ( J:31635 )

• in some mice with 8 pairs of vertebrosternal ribs, an additional sternebra is seen where the eighth pair attach

abnormal sternocostal joint morphology ( J:31635 )

• 8 instead of 7 pairs of ribs may be attached to sternum bilaterally

xiphoid process foramen ( J:31635 )

• in over half of mutants, xiphoid process is observed to have an aperture or fissure

abnormal rib development ( J:31635 )

• most newborns exhibit formation of rib heads on cervical vertebra C7 compared to no wild-type animals; ossified processes extending toward the midline are seen on the ventral side of C7

• in contrast to wild-type mice which do not form ribs on C7, a small number of mutants show rib formation or extensive rib formation on C7

increased rib number ( J:31635 )

• extra vertebrosternal ribs are seen in some mice

abnormal thoracic vertebrae morphology ( J:31635 )

• in around half of mutants, spinous process on thoracic vertebra 3 (T3) is the most prominent instead of T2 as in wild-type

nervous system

nervous system phenotype ( J:31635 )

N • cranial and facial nerves appear normal in embryos at E10.5 and 14.5

behavior/neurological

behavior/neurological phenotype ( J:31635 )

N • normal patterns of behavior are observed in postnatal animals

Genotype
MGI:3796845

ht2

• Allelic Composition: Hoxc4^tm1Hsu/Hoxc4⁺
• Genetic Background: involves: 129S/SvEv * A/J

skeleton

xiphoid process foramen ( J:31635 )

• in some mutants, xiphoid process is observed to have an aperture or fissure

abnormal rib development ( J:31635 )

• some newborns exhibit formation of rib heads on cervical vertebra C7 compared to no wild-type animals; ossified processes extending toward the midline are seen on the ventral side of C7

abnormal thoracic vertebrae morphology ( J:31635 )

• in very small number of mutants