Phenotypes associated with this allele

• Allele Symbol: Prrx2⁺
• Allele Name: wild type
• Allele ID: MGI:1857534
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prrx1^tm1Tex/Prrx1^tm1Tex Prrx2^tm1Hubr/Prrx2^+	involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB	MGI:3698249
cx2	Prrx1^tm1Tex/Prrx1^tm1Tex Prrx2^tm1Mjk/Prrx2^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3687269

Genotype
MGI:3698249

cx1

• Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex; Prrx2^tm1Hubr/Prrx2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

short Meckel's cartilage ( J:50488 )

• at E14.5, Meckel's cartilage is truncated

abnormal incisor morphology ( J:50488 )

• newborns exhibit closely spaced incisors

abnormal mandible morphology ( J:50488 )

• newborns exhibit shortened dentaries

skeleton

short Meckel's cartilage ( J:50488 )

• at E14.5, Meckel's cartilage is truncated

abnormal incisor morphology ( J:50488 )

• newborns exhibit closely spaced incisors

abnormal mandible morphology ( J:50488 )

• newborns exhibit shortened dentaries

abnormal metacarpal bone morphology ( J:50488 )

• the base of the metacarpal of the fifth digit is broader and forms an articulation with the trinagular and ulna

growth/size/body

abnormal incisor morphology ( J:50488 )

• newborns exhibit closely spaced incisors

abnormal mandible morphology ( J:50488 )

• newborns exhibit shortened dentaries

limbs/digits/tail

abnormal metacarpal bone morphology ( J:50488 )

• the base of the metacarpal of the fifth digit is broader and forms an articulation with the trinagular and ulna

Genotype
MGI:3687269

cx2

• Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex; Prrx2^tm1Mjk/Prrx2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

limbs/digits/tail

forelimb oligodactyly ( J:52212 )

• 2 of 9 (22%) show oligodactyly of forelimb autopods

polydactyly ( J:52212 )

• 4 of 9 (44%) exhbit postaxial polydactyly of forelimb autopods that is less severe than seen in double homozygous mutants; none show hindlimb preaxial polydactyly

• 1 of 9 (11%) shows duplications of the first digit of the forelimb

abnormal hindlimb zeugopod morphology ( J:52212 )

• zeugopod is shorter than in wild-type but not as short as in double homozygous mutants

craniofacial

abnormal incisor morphology ( J:51596 )

• exhibit only a single midline incisor tooth

abnormal mandible morphology ( J:51596 )

• mandible is fused rostrally

skeleton

abnormal incisor morphology ( J:51596 )

• exhibit only a single midline incisor tooth

abnormal mandible morphology ( J:51596 )

• mandible is fused rostrally

growth/size/body

abnormal incisor morphology ( J:51596 )

• exhibit only a single midline incisor tooth

abnormal mandible morphology ( J:51596 )

• mandible is fused rostrally