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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prrx1+
wild type
MGI:1857533
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Prrx1tm1Tex/Prrx1+
Prrx2tm1Hubr/Prrx2tm1Hubr 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB MGI:3698248


Genotype
MGI:3698248
cx1
Allelic
Composition		 Prrx1tm1Tex/Prrx1+
Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prrx1tm1Tex mutation (0 available); any Prrx1 mutation (32 available)
Prrx2tm1Hubr mutation (0 available); any Prrx2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:50488 )
• ~80% of newborns die within 24 hrs
• surviving newborns reach adulthood and appear healthy while most of their offspring survive with no problems

respiratory system
respiratory distress ( J:50488 )
• ~80% of newborns show respiratory problems

growth/size/body
palatal shelf hypoplasia ( J:50488 )
cleft secondary palate ( J:50488 )
• ~80% of newborns display a cleft secondary palate
distended abdomen ( J:50488 )
• ~80% of newborns display abdominal distension

craniofacial
cleft secondary palate ( J:50488 )
• ~80% of newborns display a cleft secondary palate

digestive/alimentary system
cleft secondary palate ( J:50488 )
• ~80% of newborns display a cleft secondary palate

skeleton
abnormal stylohyoid ligament morphology ( J:50488 )
• the stylohyoid ligament is chondrified




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory