All Phenotypes Zeb1<tm1Yhi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zeb1^tm1Yhi/Zeb1^tm1Yhi	B6.129P2-Zeb1^tm1Yhi	MGI:3653696
hm2	Zeb1^tm1Yhi/Zeb1^tm1Yhi	either: (involves: 129 * C3H * C57BL/6) or (involves: 129 * C57BL/6 * ICR)	MGI:3812399
hm3	Zeb1^tm1Yhi/Zeb1^tm1Yhi	involves: 129P2/OlaHsd * C57BL/6	MGI:3812428
ht4	Zeb1^tm1Yhi/Zeb1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3812429

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Abnormal thymus architecture in Zeb1^tm1Yhi/Zeb1^tm1Yhi mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:39865 )

• about 80% die within 2 days after birth, however the remaining 20% survive to adulthood

immune system

abnormal thymus development ( J:39865 )

• poorly developed thymus with no distinction of cortex and medulla

small thymus ( J:39865 )

thymus hypoplasia ( J:39865 )

• total cell number of thymus is reduced from 1/100 to 1/500 of the heterozygous littermate

abnormal T cell differentiation ( J:39865 )

• the early stage intrathymic c-kit⁺ T precursor cells are largely depleted

• development from double negative (DN) to double positive (DP) cells appears to be partially inhibited

abnormal T cell subpopulation ratio ( J:39865 )

• in peripheral lymph node tissue the CD4-CD8+ single positive cells are significantly reduced relative to CD4+CD8- single positive cells

• the relative proportion of CD4+CD8+ cells is reduced from 88% in controls to 57% in homozygous thymocytes while that of single positive cells was increased from 11 to 38%

decreased lymphocyte cell number ( J:39865 )

• the number of lymphocytes recovered from a pair of inguinal lymph nodes is reduced to about 1/10 of that from heterozygous littermates

decreased T cell number ( J:39865 )

• reduction of peripheral T cells in the spleen and lymph node

decreased thymocyte number ( J:39865 )

• number of thymocytes at E18.5 is reduced 10-fold

decreased double-positive T cell number ( J:39865 )

• the relative proportion of CD4+CD8+ cells is reduced from 88% in controls to 57% in homozygous thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:39865 )

• in peripheral lymph node tissue the CD4-CD8+ single positive cells are significantly reduced relative to CD4+CD8- single positive cells

decreased splenocyte number ( J:39865 )

• the number of splenocytes is slightly lower in homozygotes

lymph node hypoplasia ( J:39865 )

• lymph node shows reduced cellularity of the deep cortex where the T cells reside

hematopoietic system

abnormal thymus development ( J:39865 )

• poorly developed thymus with no distinction of cortex and medulla

small thymus ( J:39865 )

thymus hypoplasia ( J:39865 )

• total cell number of thymus is reduced from 1/100 to 1/500 of the heterozygous littermate

abnormal T cell differentiation ( J:39865 )

• the early stage intrathymic c-kit⁺ T precursor cells are largely depleted

• development from double negative (DN) to double positive (DP) cells appears to be partially inhibited

abnormal T cell subpopulation ratio ( J:39865 )

• in peripheral lymph node tissue the CD4-CD8+ single positive cells are significantly reduced relative to CD4+CD8- single positive cells

• the relative proportion of CD4+CD8+ cells is reduced from 88% in controls to 57% in homozygous thymocytes while that of single positive cells was increased from 11 to 38%

decreased lymphocyte cell number ( J:39865 )

• the number of lymphocytes recovered from a pair of inguinal lymph nodes is reduced to about 1/10 of that from heterozygous littermates

decreased T cell number ( J:39865 )

• reduction of peripheral T cells in the spleen and lymph node

decreased thymocyte number ( J:39865 )

• number of thymocytes at E18.5 is reduced 10-fold

decreased double-positive T cell number ( J:39865 )

• the relative proportion of CD4+CD8+ cells is reduced from 88% in controls to 57% in homozygous thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:39865 )

• in peripheral lymph node tissue the CD4-CD8+ single positive cells are significantly reduced relative to CD4+CD8- single positive cells

decreased splenocyte number ( J:39865 )

• the number of splenocytes is slightly lower in homozygotes

endocrine/exocrine glands

abnormal thymus development ( J:39865 )

• poorly developed thymus with no distinction of cortex and medulla

small thymus ( J:39865 )

thymus hypoplasia ( J:39865 )

• total cell number of thymus is reduced from 1/100 to 1/500 of the heterozygous littermate

decreased thymocyte number ( J:39865 )

• number of thymocytes at E18.5 is reduced 10-fold

Allelic Composition	Zeb1^tm1Yhi/Zeb1^tm1Yhi
Genetic Background	either: (involves: 129 * C3H * C57BL/6) or (involves: 129 * C57BL/6 * ICR)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb1^tm1Yhi mutation (2 available); any Zeb1 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:139194 )

• half of the mice die within a year from lymphomas

• all mice die by 550 days

neoplasm

increased T cell derived lymphoma incidence ( J:139194 )

• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells

• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth

• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

homeostasis/metabolism

ascites ( J:139194 )

• at 4 months of age, 64.3% of mice have enlargement of the abdomen due to ascities fluid

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:139194 )

• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells

• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth

• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
tropical spastic paraparesis		DOID:321	OMIM:159580	J:139194

Allelic Composition	Zeb1^tm1Yhi/Zeb1^tm1Yhi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb1^tm1Yhi mutation (2 available); any Zeb1 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:135179 )

• mice die shortly after birth due to failure to initiate respiration

vision/eye

abnormal iridocorneal angle ( J:135179 )

• iridocorneal adhesions lead to loss of the iridocorneal angle

anterior iris synechia ( J:135179 )

• iridocorneal adhesions are observed in E17.5 embryos

• corneolenticular and iridolenticular adhesions are also evident

increased cornea thickness ( J:135179 )

• the E17.5 cornea is more than a third thicker than controls

abnormal corneal endothelium morphology ( J:135179 )

• E15.5 embryos have higher rates of proliferation of the corneal endothelium

corneal epithelium hypoplasia ( J:135179 )

• corneal epithelium has lower rates of proliferation in E15.5 embryos, though associated keratocytes have higher rates of proliferation

abnormal corneal stroma morphology ( J:135179 )

• stromal keratocyte cells have increased rates of proliferation at E15.5

• there are higher numbers of keratocytes found in the cornea of E17.5 embryos

corneal abrasion ( J:135179 )

• corneolenticular adhesions frequently lead to corneal disruption, with the endothelium being torn away from the cornea and adhering to the lens epithelium

Allelic Composition	Zeb1^tm1Yhi/Zeb1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb1^tm1Yhi mutation (2 available); any Zeb1 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iridocorneal angle ( J:135179 )

• iridocorneal adhesions lead to loss of the iridocorneal angle

anterior iris synechia ( J:135179 )

• iridocorneal adhesions are observed in 4 month old mice

• corneolenticular and iridolenticular adhesions are also evident

increased cornea thickness ( J:135179 )

• the cornea of 4 month old mice is more than twice as thick as controls

abnormal corneal stroma morphology ( J:135179 )

• there number of keratocytes found in the cornea are doubled in 4 month old mice compared to age-matched controls

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