All Phenotypes Otx2<tm2Sla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otx2^tm2Sla
targeted mutation 2, Siew Lan Ang
MGI:1857513

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Otx2^tm1Sla/Otx2^tm2Sla	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3845407

Allelic Composition	Otx2^tm1Sla/Otx2^tm2Sla
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Sla mutation (0 available); any Otx2 mutation (50 available)
Otx2^tm2Sla mutation (0 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hindbrain development ( J:46641 )

• as determined by marker expression, the anterior hindbrain tissue corresponding to rhombomere 1 appears but is subsequently deleted unlike in wild-type mice

absent midbrain ( J:46641 )

• as determined by marker expression, the midbrain fails to form

absent forebrain ( J:46641 )

• as determined by marker expression, the forebrain fails to form

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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