Phenotypes associated with this allele

• Allele Symbol: Rbl2⁺
• Allele Name: wild type
• Allele ID: MGI:1857501
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rbl2^tm1b(EUCOMM)Hmgu/Rbl2^+	C57BL/6N-Rbl2^tm1b(EUCOMM)Hmgu/J	MGI:6263330
ht2	Rbl2^tm1Tyj/Rbl2^+	involves: 129S2/SvPas * C57BL/6	MGI:3582620
cx3	Rbl1^tm1Tyj/Rbl1^tm1Tyj Rbl2^tm1Tyj/Rbl2^+	involves: 129S2/SvPas * C57BL/6	MGI:3582650

Genotype
MGI:6263330

ht1

• Allelic Composition: Rbl2^{tm1b(EUCOMM)Hmgu}/Rbl2⁺
• Genetic Background: C57BL/6N-Rbl2^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0515_2_B06

Data Sources

IMPC Data for Rbl2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - JAX

vision/eye

persistence of hyaloid vascular system ( J:211773 )

♀

IMPC - JAX

abnormal retina morphology ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:3582620

ht2

• Allelic Composition: Rbl2^tm1Tyj/Rbl2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:34725 )

• heterozygotes appear normal and show no increase in morbidity or mortality up to 16 months of age relative to wild-type mice

Genotype
MGI:3582650

cx3

• Allelic Composition: Rbl1^tm1Tyj/Rbl1^tm1Tyj; Rbl2^tm1Tyj/Rbl2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:34725 )

• mutants die at an increased rate during the first and second week after birth; survivors fail to reach normal adult weight

limbs/digits/tail

abnormal forelimb morphology ( J:34725 )

• at 18.0 dpc, mutant mice exhibit forelimb shortening and thickening

short limbs ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a mild reduction in limb length

short forelimb ( J:34725 )

• at 18.0 dpc

reproductive system

delayed fertility ( J:34725 )

• surviving mutant mice display delayed fertility

reduced female fertility ( J:34725 )

♀ • surviving mutant females show reduced fertility

craniofacial

short snout ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a mildly shortened snout

growth/size/body

short snout ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a mildly shortened snout

decreased body weight ( J:34725 )

• mutant mice display normal weight at birth but reach only ~65% of normal weight at the age of 2-3 weeks

distended abdomen ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a slightly distended abdomen