Analysis Tools
behavior/neurological
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• mutants do not show reduced sensitivity to morphine seen in wild-type mice following partial sciatic nerve ligation (pSNL); sensitivity is similar to sham-ligated controls
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• after 9 day, mice acquire ethanol self-administration unlike wild-type mice
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• over time, mice increase their consumption of ethanol unlike wild-type mice
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• after training with 5 mg/kg morphine, wild-type mice with pSNL spend less time in the drug-paired compartment than mutants with pSNL; morphine conditioned place preference is not different with or without pSNL in mutants
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• mice exhibit increased rate of response when nose-pokes resulted in alcohol administration unlike similarly treated wild-type mice
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polyphagia
(
J:115712
)
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• male mice exhibit increased food intake compared with wild-type mice
• male mice treated with neuropeptide Y (NPY) exhibit a greater increase in food intake compared with similarly treated wild-type mice
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adipose tissue
| N |
• mice exhibit normal intrascapular brown fat weight
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• total body fat amount is increased 50% in male mice compared to in wild-type mice
• however, female mice exhibit normal fat content
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• in male mice
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• 2-fold in male mice
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• inguinal fat pad weight is increased 2-fold in male mice compared to in wild-type mice
• however, over-expression of the gene in the pituitary partially rescues the phenotype while over-expression in the central nervous system completely rescues the phenotype
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• 2-fold in male mice
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• retroperitoneal fat pad weight is increased 2-fold in male mice compared to in wild-type mice
• however, over-expression of the gene in the pituitary partially rescues the phenotype while over-expression in the central nervous system completely rescues the phenotype
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homeostasis/metabolism
| N |
• male mice exhibit normal basal metabolic rate (oxygen consumption and respiratory quotient) and T4 serum levels
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• in obese male mice
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• in obese male mice
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• mice fed a high fat diet exhibit an increase in urinary adrenaline levels compared to in similarly treated wild-type mice
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• in obese male mice
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• mice treated with neuropeptide Y (NPY) exhibit a greater increase in food intake than similarly treated wild-type mice
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• naloxone-treated mice exhibit a greater decrease in food intake than similarly treated wild-type mice
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growth/size/body
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• starting at 4 weeks and continuing through adulthood, male mice exhibit an increase in body weight compared with wild-type mice
(J:115712)
• between 4 and 8 weeks, female mice exhibit an increase in body weight compared with wild-type mice
(J:115712)
• however, over-expression of the gene in the pituitary partially rescues the phenotype while over-expression in the central nervous system completely rescues the phenotype
(J:115712)
|
cardiovascular system
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• after two weeks on a high salt diet
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nervous system
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• mice fed a high salt diet exhibit a greater increase in Fos-Li neurons in the median preoptic nucleus compared with similarly treated wild-type mice
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renal/urinary system
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• mice fed a high fat diet exhibit an increase in urinary adrenaline levels compared to in similarly treated wild-type mice
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