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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Calb1tm1Mpin
targeted mutation 1, Max-Planck-Institute for Neurobiology
MGI:1857460
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Calb1tm1Mpin/Calb1tm1Mpin involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3686772
ht2
 		Calb1tm1Mpin/Calb1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3686773
cx3
 		Calb1tm1Mpin/Calb1tm1Mpin
Pvalbtm1Swal/Pvalbtm1Swal 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3686619


Genotype
MGI:3686772
hm1
Allelic
Composition		 Calb1tm1Mpin/Calb1tm1Mpin
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calb1tm1Mpin mutation (3 available); any Calb1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:38599 )
• mutants do not display ataxia in standard environments; when challenged (with a runway test or rotarod test) coordination is severely disturbed compared to controls
• mice display a shaky tremor which usually worsens during movement; controls do not show any tremors

nervous system
abnormal nervous system electrophysiology ( J:38599 )
• dendritic calcium transients associated with complex spikes (synaptic response) upon climbing fiber stimulation is altered in mutants compared to controls; peak amplitudes are enhanced by ~80% over wild-type

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:60520 )
N
• at 4-8 months, homozygotes exhibit normal cochlear morphology, as well as normal hearing and cochlear OHC function, as assessed by baseline auditory brainstem evoked responses and DPOAEs, respectively
• at 3 weeks after exposure to a moderate noise trauma, homozygotes exhibit a similar loss of cochlear hair cells to wild-type mice, with no significant differences in permanent threshold shifts of ABR or DPOAE amplitudes




Genotype
MGI:3686773
ht2
Allelic
Composition		 Calb1tm1Mpin/Calb1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calb1tm1Mpin mutation (3 available); any Calb1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:38599 )
• 2-month old heterozygotes show significant deficits in initial trials in a thin horizontal rod test compared to controls but are significantly better than homozygotes; after first 2 sessions, no significant difference remains between mutant groups

nervous system
abnormal nervous system electrophysiology ( J:38599 )
• heterozygotes show a significant increase in dendritic calcium transients upon climbing fiber stimulation compared to controls




Genotype
MGI:3686619
cx3
Allelic
Composition		 Calb1tm1Mpin/Calb1tm1Mpin
Pvalbtm1Swal/Pvalbtm1Swal
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calb1tm1Mpin mutation (3 available); any Calb1 mutation (27 available)
Pvalbtm1Swal mutation (1 available); any Pvalb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal Purkinje cell mitochondrial morphology ( J:113147 )
• total mitochondrial volume density in Purkinje cells of mutants is increased by ~40% compared to controls, similar to Pvalb single mutants

nervous system
abnormal Purkinje cell morphology ( J:113147 )
• the surface of the membrane-enclosed cisternae just below the plasma membrane (sPL-sER) per surface of plasma membrane ratio is 30-40% smaller in Purkinje cells of mutants similar to Pvalb single mutants
abnormal Purkinje cell mitochondrial morphology ( J:113147 )
• total mitochondrial volume density in Purkinje cells of mutants is increased by ~40% compared to controls, similar to Pvalb single mutants




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory