Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation
(1 available);
any
Atp2b2 mutation
(66 available)
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behavior/neurological
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• cannot stay afloat in water
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation
(1 available);
any
Atp2b2 mutation
(66 available)
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hearing/vestibular/ear
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• no discernible auditory brainstem responses (ABR) to stimuli up to 100 dB
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• profoundly deaf
• complete deafness at 3 weeks after birth
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• VESPs are absent at the maximum stimulus intensity used
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behavior/neurological
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• becomes increasingly lethargic
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• abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior
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• highly unbalanced and uncontrolled movements starting by 12-14 days of age
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• mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface
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• walk with a hesitant and wobbly gait
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reproductive system
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• life span is normal, but neither sex breeds
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation
(1 available);
any
Atp2b2 mutation
(66 available)
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behavior/neurological
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N |
• behave as well as controls in swimming and rotarod tests when tested at 33 days of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation
(1 available);
any
Atp2b2 mutation
(66 available)
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hearing/vestibular/ear
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• at 4 to 5 weeks of age, significantly elevated sound pressure thresholds
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• hearing loss begins 4 weeks after birth and progresses rapidly to complete deafness by 12 weeks of age
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• show age-dependent hearing loss by 12 weeks of age
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• elevated threshold and reduced amplitudes
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Allelic
Composition |
Atp2b2dfw-2J/Atp2b2+
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Genetic
Background |
involves: CAST/Ei * BALB/cByJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation
(1 available);
any
Atp2b2 mutation
(66 available)
|
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hearing/vestibular/ear
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N |
• in a mapping cross heterozygosity for deaf waddler 2 Jackson is found to have normal hearing when the age related hearing loss allele is absent proving this to be the recessive deafness-enhancing modifier, which is absent in CAST/Ei
(J:38429)
(J:70964)
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hearing/vestibular/ear
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• at 4 to 6 weeks of age, significantly elevated sound pressure thresholds
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• show age-dependent hearing loss by 12 weeks of age
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hearing/vestibular/ear
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• at 4 to 6 weeks of age, significantly elevated sound pressure thresholds
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• show age-dependent hearing loss by 12 weeks of age
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Analysis Tools