All Phenotypes Hprt1<b-m2> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^b-m2
hypoxanthine guanine phosphoribosyl transferase B, mutation 2
MGI:1857298

Summary

2 genotypes

Allelic Composition	Hprt1^b-m2/Y
Genetic Background	involves: 129 * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^b-m2 mutation (1 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:115724 )

N	• mice exhibit overall similar behavior as observed in wild-type mice in open field, bridge, passive avoidance and apomorphine-induced activity tests

• male mice make more slips when climbing than escape platform in a swim test compared to Hprt1^b-m1 male mice

abnormal locomotor activation ( J:115724 )

• male mice spend less time in the center of an open field than Hprt1^b-m1 male mice

homeostasis/metabolism

decreased dopamine level ( J:115724 )

• striatal concentrations of dopamine are lower than in wild-type mice

Allelic Composition	Hprt1^b-m2/Y
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^b-m2 mutation (1 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:3354 , J:15485 )

N	• mice exhibit normal behavior (J:3354) (J:15485)

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