Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Jae mutation
(2 available);
any
Ntf3 mutation
(24 available)
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mortality/aging
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• mutants die soon after birth from cardiac defects
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nervous system
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• no spindle bundles are seen
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• a 63% decrease compared to wild-type in the overall number of dorsal root ganglia neurons at L4 is seen in newborn mice
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• essentially no proprioceptive neurons are present
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muscle
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• no spindle bundles are seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Jae mutation
(2 available);
any
Ntf3 mutation
(24 available)
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mortality/aging
behavior/neurological
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• display an inability to position the extremities properly when attempting to move
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• exhibit a tendency of all four limbs to intermittently stiffen in an extensor posture
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growth/size/body
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• weigh 20% less than controls at birth
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muscle
nervous system
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• fewer stellate ganglion neurons at P0 and P60 than in heterozygotes or wild-type
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• show no evidence of afferent nerve fiber-muscle contacts
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• loss of carbonic anhydrase (CA) positive neurons, which are mostly L4 dorsal root ganglion neurons
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• central branch of the proprioceptive Ia fibers innvervating spinal cord layer IX is absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Jae mutation
(2 available);
any
Ntf3 mutation
(24 available)
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nervous system
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• no muscle spindles are found in the soleus muscle during development and at later stages
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• 70% of dorsal root ganglia neurons are lost relative to in wild-type mice
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• proprioceptive neurons are lost
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muscle
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• no muscle spindles are found in the soleus muscle during development and at later stages
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Jae mutation
(2 available);
any
Ntf3 mutation
(24 available)
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nervous system
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• on P1 the fungiform papillae of the tongue are partially denervated
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• innervation of the somatosensory prominences is virtually absent
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Allelic
Composition |
Ntf3tm1Jae/Ntf3+
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Genetic
Background |
involves: 129S4/SvJae * BALB/c |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Jae mutation
(2 available);
any
Ntf3 mutation
(24 available)
|
|
|
nervous system
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• fewer stellate ganglion neurons at P0 and P60 than in wild-type
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• mice exhibit a 17% loss in sensory neurons in the dorsal root ganglion
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• mice exhibit a loss of myelinated fibers in the dorsal root ganglion
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cardiovascular system
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• adults exhibit lower sympathetic tonus than wild-type
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• adults exhibit lower resting heart rates than wild-type
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homeostasis/metabolism
muscle
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• 50% reduction of muscle spindles
(J:23882)
• muscles exhibit fewer myelinated fibers than in wild-type mice (52+/-4 compared to 76+/-2 in wild-type mice)
(J:53825)
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nervous system
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• no muscle spindles are found in the soleus muscle during development and at later stages
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• the number of dorsal root ganglia neurons in L4 is increased by 50% relative to in wild-type mice
• while proprioceptive neurons are retained, the somata is reduced by 70%
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• proprioceptive neurons fail to innervate their target muscles
• proprioceptive axons fail to extend into the ventral horn
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muscle
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• no muscle spindles are found in the soleus muscle during development and at later stages
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mortality/aging
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• few mice survive past 3 weeks of age
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nervous system
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• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice
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• 31% of soleus muscles are devoid of muscle spindles
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• mice exhibit a 78% loss in sensory neurons in the dorsal root ganglion
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• mice exhibit a loss of 82% myelinated fibers in the dorsal root ganglion
• mice exhibit a loss of 75% of dorsal root ganglion neurons
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• at E14.5, Ia neuron projections in the dorsal root ganglion are severely reduced
• mice exhibit a 90% loss of proprioreceptive neurons in the dorsal root ganglion
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• at E14.5, L4 is smaller than in wild-type mice due to a 12.1-fold increase in apoptosis
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behavior/neurological
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• mice exhibit dystonia during the first two weeks after birth but not during adulthood
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• mice exhibit ataxia during the first two weeks after birth but not during adulthood
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• mice exhibit an unstable gait and mild posturing of extremities during the first two weeks after birth but not during adulthood
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muscle
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• mice exhibit dystonia during the first two weeks after birth but not during adulthood
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• muscles exhibit fewer myelinated fibers than in wild-type mice (26+/-2 compared to 76+/-2 in wild-type mice)
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• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice
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• 31% of soleus muscles are devoid of muscle spindles
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• mice that survive longer than 3 weeks exhibit flexor spasms and uplifting of hindlimbs during weeks 3 to 4
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growth/size/body
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• mice weight 10% to 30% less than wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Jae mutation
(2 available);
any
Ntf3 mutation
(24 available)
Tg(Myog-Ntf3)5160Wds mutation
(0 available)
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mortality/aging
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• mutants die soon after birth presumably from cardiac defects similar to Ntf3tm1Jae homozygotes
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nervous system
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• abnormal clusters of spindle bundles are seen
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• a 54% decrease compared to wild-type in the overall number of dorsal root ganglia neurons at L4 is seen in newborn mice this represents a partial recovery from the 63% deficiency seen in Ntf3tm1Jae homozygotes
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• the number of proprioceptive neurons and spindle bundles are decreased in most skeletal muscles however this decrease is not as great as in Ntf3tm1Jae homozygotes
• this rescue is muscle specific with no recovery in the soleus muscles and almost complete recovery in the medial gastrocnemius
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muscle
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• abnormal clusters of spindle bundles are seen
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Analysis Tools