Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2tm1Sho mutation
(1 available);
any
Nfe2 mutation
(20 available)
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mortality/aging
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• less than 10% of mice survive to adulthood
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• a majority of mice die during the neonatal period due to hemorrhage
• less than 10% of mice survive to adulthood
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hematopoietic system
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• mice that survive into adulthood exhibit intermittent anemia
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• megakaryocytes exhibit an increase in size compared to in wild-type mice, a paucity of granules, hyperlobulation of the nucleus, and striking emperipolesis
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• 2- to 4-fold increase of megakaryocytes in the spleen and bone marrow compared to in wild-type mice
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• mice exhibit decreased hemoglobin content that cannot be explained by blood loss or iron deficiency
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• mice exhibit microcytosis that cannot be explained by blood loss or iron deficiency
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• despite normal thrombopoeitin action, late megakaryocyte maturation is blocked
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• megakaryocytes exhibit striking emperipolesis (nonphagocytic inclusion of other blood cells within the cytoplasm)
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cardiovascular system
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• after birth mice exhibit internal hemorrhages in the peritoneal cavity and the wall of the urinary bladder
• a majority of mice die during the neonatal period due to hemorrhage
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growth/size/body
integument
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2tm1Sho mutation
(1 available);
any
Nfe2 mutation
(20 available)
|
|
|
mortality/aging
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• less than 10% of mice survive to adulthood
|
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• a majority of mice die during the neonatal period due to hemorrhage
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• less than 10% of mice survive to adulthood
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hematopoietic system
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• mice that survive into adulthood exhibit intermittent anemia
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• megakaryocytes exhibit an increase in size compared to in wild-type mice, a paucity of granules, hyperlobation of the nucleus and emperipoiesis
(J:20132)
• megakaryocytes are larger than normal and exhibit markers of maturity but never generate proplatelets even after prolonged culture conditions in which wild-type megakaryocytes produce proplatelets
(J:106670)
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• 2- to 4-fold compared to in wild-type mice
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• mice exhibit decreased hemoglobin content that cannot be explained by blood loss or iron deficiency
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• mice exhibit microcytosis that cannot be explained by blood loss or iron deficiency
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• mice exhibit thrombocytopenia that is cell autonomous
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• the number of osteoclasts is increased by greater than 3-fold compared to in wild-type mice and is accompanied by a proportional increase in osteoblasts
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• despite normal thrombopoeitin action, late megakaryocyte maturation is blocked
(J:20132)
• megakaryocytes are larger than normal and exhibit markers of maturity but never generate proplatelets even after prolonged culture conditions in which wild-type megakaryocytes produce proplatelets
(J:106670)
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skeleton
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• the number of osteoclasts is increased by greater than 3-fold compared to in wild-type mice and is accompanied by a proportional increase in osteoblasts
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• trabecular bone volume for the entire medullary canal is increased 20-fold compared to in wild-type mice
• at 5 to 9 months of age, the trabecular bone volume is increased 2- to 3-fold compared to in wild-type mice
• at 5 months, the diaphyseal shafts are occluded with bone unlike in wild-type mice
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• at 5 to 9 months of age, the cortical bone is increased 2- to 3-fold compared to in wild-type mice
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• the number of osteoblasts is increased by greater than 3-fold compared to in wild-type mice and is accompanied by a proportional increase in osteoclasts
• osteoblast proliferation is increased up to 6-fold when cultured with megakaryocytes compared to in wild-type mice
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• bone formation is increased 2.7-fold compared to in wild-type mice
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cardiovascular system
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• after birth mice exhibit internal hemorrhages in the peritoneal cavity and the wall of the urinary bladder
• a majority of mice die during the neonatal period due to hemorrhage
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immune system
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• the number of osteoclasts is increased by greater than 3-fold compared to in wild-type mice and is accompanied by a proportional increase in osteoblasts
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growth/size/body
integument
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2tm1Sho mutation
(1 available);
any
Nfe2 mutation
(20 available)
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mortality/aging
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• mice exhibit a slightly quicker average time between exposure to the Friend virus and sacrifice compared to wild-type mice
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immune system
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• following exposure with the Friend virus, mice exhibit an increase in spleen size compared to similarly treated wild-type mice
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• mice exhibit a slightly quicker average time between exposure to the Friend virus and sacrifice compared to wild-type mice
• following exposure with the Friend virus, mice exhibit a shorter time span to tumor development and an increase in tumorigenic spleen volume compared to wild-type mice
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neoplasm
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• following exposure with the Friend virus, mice exhibit a shorter time span to tumor development and an increase in tumorigenic spleen volume compared to wild-type mice
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hematopoietic system
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• following exposure with the Friend virus, mice exhibit an increase in spleen size compared to similarly treated wild-type mice
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growth/size/body
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• following exposure with the Friend virus, mice exhibit an increase in spleen size compared to similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l3tm1Vbl mutation
(0 available);
any
Nfe2l3 mutation
(28 available)
Nfe2tm1Sho mutation
(1 available);
any
Nfe2 mutation
(20 available)
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mortality/aging
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• reduced survival to adulthood but some did survive
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Ney mutation
(0 available);
any
Nfe2l2 mutation
(88 available)
Nfe2tm1Sho mutation
(1 available);
any
Nfe2 mutation
(20 available)
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hematopoietic system
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• mice exhibit anemia that is no more severe that in Nfe2tm1Sho homozygotes
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• as in Nfe2tm1Sho homozygotes
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