All Phenotypes Myod1<tm1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myod1^tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857221

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myod1^tm1Jae/Myod1^tm1Jae	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2175133
hm2	Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae	MGI:3798779
cn3	Myf5^tm1(cre)Mrc/Myf5⁺ Myod1^tm1Jae/Myod1^tm1Jae Pax7^tm1.1Thbr/Pax7^tm1.1Thbr	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5548074
cx4	Fgf6^tm1Thbr/Fgf6^tm1Thbr Myod1^tm1Jae/Myod1^tm1Jae	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	MGI:3722601
cx5	Myf5^tm1Pas/Myf5⁺ Myod1^tm1Jae/Myod1^tm1Jae	involves: 129 * C57BL/6 * DBA/2	MGI:3055415
cx6	Myf5^tm1Pas/Myf5^tm1Pas Myod1^tm1Jae/Myod1^tm1Jae	involves: 129 * C57BL/6 * DBA/2	MGI:3055413
cx7	Myf5^tm1Pas/Myf5^tm1Pas Myod1^tm1Jae/Myod1⁺	involves: 129 * C57BL/6 * DBA/2	MGI:3055414
cx8	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog^tm1Whk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714533
cx9	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714518
cx10	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1⁺ Myog^tm1Whk/Myog⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714517
cx11	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714510
cx12	Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae * C57BL/10ScSn	MGI:3784305
cx13	Myf5^tm3(cre)Sor/Myf5^tm3(cre)Sor Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae * C57BL/6J	MGI:3713926
cx14	Myf5^tm1Tajb/Myf5^tm1Tajb Myod1^tm1Jae/Myod1^tm1Jae	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055418
cx15	Myf5^tm2Tajb/Myf5^tm2Tajb Myod1^tm1Jae/Myod1^tm1Jae	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055420

Allelic Composition	Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:3070 )

Allelic Composition	Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:168843 )

• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

increased satellite cell number ( J:128921 )

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:168843 )

• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

Allelic Composition	Myf5^tm1(cre)Mrc/Myf5⁺ Myod1^tm1Jae/Myod1^tm1Jae Pax7^tm1.1Thbr/Pax7^tm1.1Thbr
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased satellite cell number ( J:202693 )

• more so than in Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Myf5^tm1(cre)Mrc/Myf5⁺ mice at day 110

Allelic Composition	Fgf6^tm1Thbr/Fgf6^tm1Thbr Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf6^tm1Thbr mutation (0 available); any Fgf6 mutation (7 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased litter size ( J:42574 )

Allelic Composition	Myf5^tm1Pas/Myf5⁺ Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Pas mutation (1 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:92799 )

Allelic Composition	Myf5^tm1Pas/Myf5^tm1Pas Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• no skeletal myogenesis is seen at any developmental stage

absent skeletal muscle ( J:92799 )

• mutants lack skeletal muscle throughout the body including the head

Allelic Composition	Myf5^tm1Pas/Myf5^tm1Pas Myod1^tm1Jae/Myod1⁺
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:92799 )

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:61155 )

• die within minutes of birth

growth/size/body

decreased fetal size ( J:61155 )

• E18.5 mutants show a reduction in body mass

muscle

abnormal muscle development ( J:61155 )

• marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers

• myoblasts from neonates are unable to differentiate in vitro

muscle hypoplasia ( J:61155 )

• severe muscle deficiency with almost no muscle fibers; the few fibers that are present are extremely thin and underdeveloped

• tongue, back, limb, and skeletal muscle are all affected comparably unlike in single Myog homozygous mutants

skeleton

abnormal rib morphology ( J:61155 )

• the average lengths of the ossified portions of the ribs are 30% shorter than normal at E15.5, however the ribs reach the sternum

kyphosis ( J:61155 )

• severe

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:48809 )

• myogenesis is arrested at the level seen in single homozygous Myog mutants

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1⁺ Myog^tm1Whk/Myog⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48809 )

• mutants are normal, viable and fertile and appear to have normal muscle

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48809 )

• die within minutes after birth due to an inability to breathe

growth/size/body

decreased body size ( J:48809 )

• decrease in body mass at E16.5

muscle

centrally nucleated skeletal muscle fibers ( J:48809 )

• nuclei are centrally located instead of in the periphery as in wild-type

decreased skeletal muscle fiber number ( J:48809 )

• severe skeletal muscle deficiency with only residual muscle fibers surrounded by mononucleated cells

absent skeletal muscle ( J:48809 )

• appear to lack skeletal muscle beginning at E14.5

skeleton

abnormal rib morphology ( J:48809 )

• show rib defects indistinguishable from Myf6^tm1Eno homozygotes

kyphosis ( J:48809 )

• show abnormal curvature of the spine starting around E14.5

adipose tissue

abnormal adipose tissue distribution ( J:48809 )

• accumulate brown fat at the apex of the neck beginning at E14.5

respiratory system

respiratory failure ( J:48809 )

• die within minutes after birth due to an inability to breathe

Allelic Composition	Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129S4/SvJae * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (30 available); any Dmd mutation (153 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae mice develop cardiomyopathy

mortality/aging

premature death ( J:52248 )

• premature death around 12 months of age

cardiovascular system

increased myocardial fiber size ( J:52248 )

• ventricles contain regions in which individual cardiac myocytes are enlarged; these hypertrophic myocytes are more common in the left ventricle than the right ventricle

• cardiac myocyte hypertrophy precedes necrosis

myocardium necrosis ( J:52248 )

• fibrotic areas are composed of necrotic myocytes

increased heart weight ( J:52248 )

abnormal heart ventricle morphology ( J:52248 )

• hearts show an increase in ventricular diameter without a change in the thickness of the ventricular wall

cardiac fibrosis ( J:52248 )

• more than 50% of mutants show evidence of fibrosis at 10 months of age, while more than 80% display extensive fibrosis by 12 months of age

• fibrosis is seen in the left ventricle and only rarely in the right ventricle and are confined primarily to the epicardial region of the left ventricle

cardiac interstitial fibrosis ( J:52248 )

• fibrotic areas are composed of necrotic myocytes associated with interstitial fibrosis

dilated cardiomyopathy ( J:52248 )

• progressive development of dilated cardiomyopathy that is evident by 5 months of age

muscle

increased myocardial fiber size ( J:52248 )

• ventricles contain regions in which individual cardiac myocytes are enlarged; these hypertrophic myocytes are more common in the left ventricle than the right ventricle

• cardiac myocyte hypertrophy precedes necrosis

myocardium necrosis ( J:52248 )

• fibrotic areas are composed of necrotic myocytes

dilated cardiomyopathy ( J:52248 )

• progressive development of dilated cardiomyopathy that is evident by 5 months of age

growth/size/body

increased heart weight ( J:52248 )

cellular

myocardium necrosis ( J:52248 )

• fibrotic areas are composed of necrotic myocytes

cardiac interstitial fibrosis ( J:52248 )

• fibrotic areas are composed of necrotic myocytes associated with interstitial fibrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:52248

Allelic Composition	Myf5^tm3(cre)Sor/Myf5^tm3(cre)Sor Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:65301 )

abnormal myotube morphology ( J:65301 )

• mutant embryos do not form skeletal myotubes

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• only the double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• skeletal muscle differentiation is seen at E12.5 however myogenesis is still severely impaired such that mutants essentially lack skeletal muscle at birth

absent skeletal muscle ( J:92799 )

• mutants essentially lack skeletal muscle throughout the body including the head

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• only the double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• skeletal muscle differentiation is seen at E12.5 however myogenesis is still severely impaired such that mutants essentially lack skeletal muscle at birth

absent skeletal muscle ( J:92799 )

• mutants essentially lack skeletal muscle throughout the body including the head

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