Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation
(2 available);
any
Gba1 mutation
(43 available)
|
|
|
mortality/aging
behavior/neurological
growth/size/body
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• underweight, evident at birth
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hematopoietic system
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• macrophages in liver, bone marrow, spleen, and brain show lysosomal lipid accumulation
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homeostasis/metabolism
immune system
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• macrophages in liver, bone marrow, spleen, and brain show lysosomal lipid accumulation
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respiratory system
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• respire abnormally from birth
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Allelic Composition |
Gba1tm2Ggb/Gba1tm1Nsb
|
|
Genetic Background |
involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation
(2 available);
any
Gba1 mutation
(43 available)
Gba1tm2Ggb mutation
(0 available);
any
Gba1 mutation
(43 available)
|
|
|
cardiovascular system
|
• small accumulations of glucosylceramide at 9 months of age
|
hematopoietic system
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• small numbers of storage cells at 8-9 months of age
• small accumulations of glucosylceramide at 9 months of age
|
immune system
|
• small numbers of storage cells at 8-9 months of age
• small accumulations of glucosylceramide at 9 months of age
|
liver/biliary system
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• small accumulations of glucosylceramide at 9 months of age
|
respiratory system
|
• small accumulations of glucosylceramide at 9 months of age
|
Allelic Composition |
Gba1tm3Ggb/Gba1tm1Nsb
|
|
Genetic Background |
involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation
(2 available);
any
Gba1 mutation
(43 available)
Gba1tm3Ggb mutation
(0 available);
any
Gba1 mutation
(43 available)
|
|
|
cardiovascular system
|
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age
|
hematopoietic system
|
• small numbers of storage cells at 3-4 months of age
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age
|
immune system
|
• small numbers of storage cells at 3-4 months of age
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age
|
liver/biliary system
|
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age
|
respiratory system
|
• small accumulations of glucosylceramide (2X wild-type values) at 6.5 months of age
|
Allelic Composition |
Gba1tm4Ggb/Gba1tm1Nsb
|
|
Genetic Background |
involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation
(2 available);
any
Gba1 mutation
(43 available)
Gba1tm4Ggb mutation
(0 available);
any
Gba1 mutation
(43 available)
|
|
|
cardiovascular system
|
• large numbers of storage cells at 3 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age
|
hematopoietic system
|
• small numbers of storage cells at 3-4 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age
|
immune system
|
• small numbers of storage cells at 3-4 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age
|
liver/biliary system
|
• small numbers of storage cells at 3 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age
|
respiratory system
|
• large numbers of storage cells at 3 months of age
• accumulations of glucosylceramide (4X wild-type values) at 6.5 months of age
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Bst mutation
(0 available);
any
Gba1 mutation
(43 available)
Gba1tm1Nsb mutation
(2 available);
any
Gba1 mutation
(43 available)
Gba/Mtx1tm1Bst mutation
(0 available);
any
Mtx1 mutation
(20 available)
|
|
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mortality/aging
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• animals die within 24 hours of birth
|
homeostasis/metabolism