Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm1Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
Allelic
Composition |
Acetm1Unc/Acetm1Unc
|
|
Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm1Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
cellular
 |
• very few mutant sperm progress beyond the two oviduct regions nearest the uterus at 1 hr after mating, whereas significantly more wild-type sperm reach the extramural uterotubal junction and the lower and upper isthmus regions of the oviducts under identical conditions
|
mortality/aging
|
|
• intercrossing of heterozygotes results in about 11% homozygous mutant mice compared with the expected 25%; the cause of this deviation has not been determined
• at weaning, the proportions of wild-type, heterozygous and homozygous offspring differ significantly from the expected 1:2:1 Mendelian ratios
|
reproductive system
 N |
• females are fertile
(J:25284)
|
|
N |
• males show normal testes morphology, normal spermatogenesis, and normal sperm count and morphology
(J:25284)
• sperm show no significant differences in assays of viability, motility, capacitation, and induction of the acrosome reaction relative to wild-type sperm
(J:46177)
|
|
|
• very few mutant sperm progress beyond the two oviduct regions nearest the uterus at 1 hr after mating, whereas significantly more wild-type sperm reach the extramural uterotubal junction and the lower and upper isthmus regions of the oviducts under identical conditions
|
|
|
• 2 pups in a single litter
|
|
|
• 80% (4 of 5) males are unable to sire offspring
• reduced fertility putatively due to an impaired ability to fertilize ova
|
|
|
• mutant sperm show defects in transport within the oviducts and in binding to zonae pellucidae
• even those mutant sperm that reach the oviductal ampulla are less likely to fertilize eggs because of their reduced capacity for zona binding
|
|
|
• sperm from male homozygotes achieve in vivo fertilization at a reduced frequency: >65% of eggs from wild-type matings become fertilized and develop to the 8-cell stage or beyond compared with <5% of eggs harvested from wild-type females inseminated by homozygous mutant males
|
|
|
• mutant sperm show defects in binding to zonae pellucidae
|
cardiovascular system
|
|
• intrarenal arteries display significant mural hypercellularity and thickening with narrowing of the lumen
|
|
|
• blood pressure is reduced by ~35 mm Hg in both males and females
|
renal/urinary system
|
|
• intrarenal arteries display significant mural hypercellularity and thickening with narrowing of the lumen
|
|
|
• focal areas of cortical thinning
|
|
|
• shrinkage of tubules associated with a wedge-shaped zone of cortical atrophy in the subcapsular renal cortex
|
immune system
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm1Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
Allelic
Composition |
Acetm1Unc/Ace+
|
|
Genetic
Background |
involves: 129P2/OlaHsd |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm1Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
cardiovascular system
growth/size/body
Allelic
Composition |
Acetm1Unc/Ace+
|
|
Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm1Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
mortality/aging
|
|
• at weaning, the proportions of wild-type and heterozygous offspring differ significantly from the expected Mendelian ratios; the cause of this deviation has not been determined
|
cardiovascular system
|
|
• blood pressure is reduced by 15-20 mm Hg in males; females display normal blood pressure
|
growth/size/body
|
|
• compared to in Acetm3Unc heterozygotes when fed a high fat diet
|
adipose tissue
|
|
• when fed a high fat diet, peri-epididymal adipose tissue is increased compared to in Acetm3Unc heterozygotes
|
reproductive system
|
N |
• males heterozygotes sire wild-type and heterozygous offspring at an indistinguishable frequency, indicating functionally intact sperm
|
endocrine/exocrine glands
|
|
• compared to in Acetm3Unc heterozygotes when fed a high fat diet
|
homeostasis/metabolism
cardiovascular system
|
|
• similar to Acetm1Unc homozygotes however normal cardiac contractility is seen unlike Acetm1Unc homozygotes
|
homeostasis/metabolism
renal/urinary system
|
|
• similar to Acetm1Unc homozygotes
|
cardiovascular system
|
|
• similar to Acetm1Unc homozygotes however normal cardiac contractility is seen at 6 months of age unlike in Acetm1Unc homozygotes
|
homeostasis/metabolism
renal/urinary system
|
|
• similar to Acetm1Unc homozygotes
|
Analysis Tools