Phenotypes associated with this allele

• Allele Symbol: Qki^qk-kt1
• Allele Name: quaking kt1
• Allele ID: MGI:1857101
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qki^qk-kt1/Qki^qk-kt1	involves: STOCK t^w5	MGI:5639298
ht2	Qki^e5/Qki^qk-kt1	involves: 101/Rl * C57BL/6J	MGI:3607584
ht3	Qki^qk-k2/Qki^qk-kt1	involves: C57BL/6 * CBA/Ca * STOCK t^w5	MGI:3720799

Genotype
MGI:5639298

hm1

• Allelic Composition: Qki^qk-kt1/Qki^qk-kt1
• Genetic Background: involves: STOCK t^w5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:55007 )

• lethality between E8.5-E11.5

embryo

abnormal rostral-caudal axis patterning ( J:55007 )

• disorganized axis observed in embryos abnormal at E8.5

abnormal rostral-caudal patterning of the somites ( J:55007 )

• frequently resulted in neural kinking

abnormal head fold morphology ( J:55007 )

• small or open head folds with hemorrhaging and abnormal ventricle formation seen in older embryos

cardiovascular system

abnormal heart development ( J:55007 )

• enlarged pericardial sacs

Genotype
MGI:3607584

ht2

• Allelic Composition: Qki^e5/Qki^qk-kt1
• Genetic Background: involves: 101/Rl * C57BL/6J

behavior/neurological

tremors ( J:102038 )

seizures ( J:102038 )

• but no ataxia

nervous system

seizures ( J:102038 )

• but no ataxia

Genotype
MGI:3720799

ht3

• Allelic Composition: Qki^qk-k2/Qki^qk-kt1
• Genetic Background: involves: C57BL/6 * CBA/Ca * STOCK t^w5

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:27474 )

• embryos are dead by E9