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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Qkiqk-k2
quaking k2
MGI:1857100
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Qkiqk-k2/Qkiqk-k2 involves: C57BL/6 * CBA/Ca MGI:3720798
ht2
Qkie5/Qkiqk-k2 involves: 101/Rl * C57BL/6J * CBA/Ca MGI:3607586
ht3
Qkiqk-k2/Qkiqk-kt1 involves: C57BL/6 * CBA/Ca * STOCK tw5 MGI:3720799
ht4
Qkiqk-k2/Qkiqk-kt4 involves: C57BL/6 * CBA/Ca * STOCK tw5 MGI:3720801


Genotype
MGI:3720798
hm1
Allelic
Composition
Qkiqk-k2/Qkiqk-k2
Genetic
Background
involves: C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-k2 mutation (1 available); any Qki mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Growth retardation and impaired vascular development in Qkiqk-l1/Qkiqk-l1 and Qkiqk-k2/Qkiqk-k2 embryos

mortality/aging
• homozygous embryos show arrested development and death starting around E10-11 (J:75828)
• homozygotes die at midgestation due to lack of vascular remodeling (J:106770)

embryo
• at E10.5, large vitelline vessels have not formed and capillary plexus is dilated and unremodeled (J:106770)
• at E9, embryos are disorganized
• at E9, one embryo had a lost of proper axis determination
• all embryos arrest at E9 to E9.5
• at E10.5, embryos are growth-retarded
• at E9 embryos were the size of E8 to E8.5 embryos with no somites
• at E9, head folds are diminished
• at E9, embryos lack somites
• fibronectin deposition is decreased between the visceral endoderm and the mesoderm and around the mesoderm in the yolk sac compared to wild-type
• treatment of pregnant dams with dietary retinoic acid restores fibronectin deposition in mutant yolk sacs
• in yolk sac at E8.5, apoptotic visceral endodermal cell number is increased 7-fold relative to wild-type littermates; apoptotic cells are restricted to extraembryonic region of visceral endoderm
• integrity is compromised
• treatment of pregnant dams with dietary retinoic acid reduces apoptotic cell numbers to control-fed wild-type levels

growth/size/body
• one embryo had a large beating heart
• at E10.5, embryos are growth-retarded
• at E9 embryos were the size of E8 to E8.5 embryos with no somites

cardiovascular system
N
• cardiac muscle is differentiated and intact at E9.5 and hearts show normal association of cardiac cells
• cardiac function of E9.5 hearts assessed in culture shows normal contraction rates compared to normal hearts
• at E8.5, endothelial cells in mutant yolk sacs demonstrate a 2-fold increase in mitotic index (meaning decreased cell proliferation)
• at E10.5, embryos lack mature vasculature formation in the head and between somites
• vessel structures are disorganized and do not form a remodeled capillary network
• blood vessels in embryo are underdeveloped at E9.5
• vessels display decreased size and less branching in midbrain, trunk, and intersegmental regions of the somites
• no mural cell recruitment to endothelial tube structures occurs in mutants at E9.5 while midbrain vessels in wild-type embryos have been invested by mural cells at this stage
• at E10.5, large vitelline vessels have not formed and capillary plexus is dilated and unremodeled (J:106770)
• at E9.5, hearts are less compact than normal (J:75828)
• hearts are less tightly looped than wild-type at E10.5
• one embryo had a large beating heart
• some embryos develop enlarged fluid-filled pericardial sacs surround beating heart (J:75828)
• seen at E10.5 (J:106770)

nervous system
N
• neurogenesis occurs normally in mutants
• at E9, one embryo had partial duplication of neural tissue
• at E9, head folds are diminished

limbs/digits/tail
• tail formation and growth is blunted, observed at E10.5

homeostasis/metabolism
• some embryos develop enlarged fluid-filled pericardial sacs surround beating heart (J:75828)
• seen at E10.5 (J:106770)




Genotype
MGI:3607586
ht2
Allelic
Composition
Qkie5/Qkiqk-k2
Genetic
Background
involves: 101/Rl * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkie5 mutation (0 available); any Qki mutation (26 available)
Qkiqk-k2 mutation (1 available); any Qki mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice live beyond 5 months of age

behavior/neurological
• but no ataxia

nervous system
• but no ataxia




Genotype
MGI:3720799
ht3
Allelic
Composition
Qkiqk-k2/Qkiqk-kt1
Genetic
Background
involves: C57BL/6 * CBA/Ca * STOCK tw5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-k2 mutation (1 available); any Qki mutation (26 available)
Qkiqk-kt1 mutation (0 available); any Qki mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3720801
ht4
Allelic
Composition
Qkiqk-k2/Qkiqk-kt4
Genetic
Background
involves: C57BL/6 * CBA/Ca * STOCK tw5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-k2 mutation (1 available); any Qki mutation (26 available)
Qkiqk-kt4 mutation (0 available); any Qki mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable mice are obtained

embryo
• all embryos arrest at E9 to E9.5





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory