Analysis Tools
mortality/aging
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• some affected mice have a normal palate and survive to sexual maturity
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• most affected mice die within 2 days of birth due to cleft palate
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craniofacial
cleft palate
(
J:13119
)
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• leads to death within a day or two for most mutant mice
|
limbs/digits/tail
short tail
(
J:13119
)
growth/size/body
cleft palate
(
J:13119
)
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• leads to death within a day or two for most mutant mice
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• affected mice that survive maintain size differential compared to normal siblings throughout life
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reproductive system
renal/urinary system
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• at birth kidneys have only minor histological abnormalities but are deficient in alkaline phosphatese
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skeleton
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• there is an overall reduction in length but not width of midline structures, particularly at the anterior and posterior ends
• observable especially in the tail by E10.5
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• fusions of ribs and sternebrae are frequently seen
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• there may be a small extra pair of ribs
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rib fusion
(
J:13014
)
digestive/alimentary system
cleft palate
(
J:13119
)
|
• leads to death within a day or two for most mutant mice
|
