Phenotypes associated with this allele

• Allele Symbol: Tub^tm1Rok
• Allele Name: targeted mutation 1, Rosana Kapeller
• Allele ID: MGI:1857081
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tub^tm1Rok/Tub^tm1Rok	C57BL/6-Tub^tm1Rok	MGI:2174794

Genotype
MGI:2174794

hm1

• Allelic Composition: Tub^tm1Rok/Tub^tm1Rok
• Genetic Background: C57BL/6-Tub^tm1Rok

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:59994 )

• at 8 weeks of life, homozygotes exhibit increased weight gain, such that by 19 weeks their weight is nearly twice that of wild-type mice

increased susceptibility to age related obesity ( J:59994 )

• both male and female homozygotes develop late-onset obesity

• however, homozygotes show no obvious defects at birth or in the neonatal period

vision/eye

increased retina apoptosis ( J:59994 )

• at 8 weeks of life, homozygotes display significant apoptosis of photoreceptor cells

decreased retina photoreceptor cell number ( J:59994 )

• at 8 weeks of life, homozygotes show a significant reduction of photoreceptors

thin retina outer nuclear layer ( J:59994 )

• at 8 weeks of life, homozygotes show a significant reduction of the outer nuclear layer

retina degeneration ( J:59994 )

• at 8 weeks of life, homozygotes display severe retinal degeneration, with marked loss of photoreceptor and outer nuclear layers relative to wild-type mice

• the remaining layers of the retina appear unaffected

nervous system

decreased retina photoreceptor cell number ( J:59994 )

• at 8 weeks of life, homozygotes show a significant reduction of photoreceptors

cellular

increased retina apoptosis ( J:59994 )

• at 8 weeks of life, homozygotes display significant apoptosis of photoreceptor cells