Phenotypes associated with this allele

• Allele Symbol: Adamtsl2^stb
• Allele Name: stubby
• Allele ID: MGI:1857056
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamtsl2^stb/Adamtsl2^stb	Not Specified	MGI:3713699

Genotype
MGI:3713699

hm1

• Allelic Composition: Adamtsl2^stb/Adamtsl2^stb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

decreased cranium height ( J:5109 )

• skull length is 92% of normal

domed cranium ( J:5109 )

• domed-shaped head is seen at 4-5 days of age

growth/size/body

abnormal body size ( J:5109 )

• mutants are shorter and stockier

decreased body length ( J:5109 )

• body length is reduced to 89% of normal

abnormal body weight ( J:5109 )

• organ weights at 29-32 days of age 77-92% of normal, except the lungs and kidneys which are comparable in size to controls

disproportionate dwarf ( J:5109 )

postnatal growth retardation ( J:5109 )

• growth is slightly retarded during the first 4 weeks and adults reach a weight within 3-6 gm of normal siblings

limbs/digits/tail

short limbs ( J:5109 )

• limbs are slightly shortened

short tail ( J:5109 )

• tail length is reduced to 86% of normal

thick tail ( J:5109 )

reproductive system

small testis ( J:5109 )

♂ • testes weight at 29-32 days of age is 57% of normal

abnormal sperm number ( J:5109 )

♂ • testes that produce no sperm were found in some mutants

reduced male fertility ( J:5109 )

♂ • most males do not breed

skeleton

abnormal long bone epiphyseal plate morphology ( J:5109 )

abnormal long bone epiphyseal plate proliferative zone ( J:5109 )

• proliferating cartilage cell columns are shorter

decreased width of hypertrophic chondrocyte zone ( J:5109 )

decreased long bone epiphyseal plate size ( J:5669 )

• thinner epiphyseal plate

decreased length of long bones ( J:5109 )

• limb bone lengths are 85 to 90% of normal

abnormal axial skeleton morphology ( J:5109 )

• axial skeleton is slightly shortened

decreased cranium height ( J:5109 )

• skull length is 92% of normal

domed cranium ( J:5109 )

• domed-shaped head is seen at 4-5 days of age

abnormal trabecular bone morphology ( J:5109 )

• primary trabeculae are shorter, less numerous, and not aligned as well as in controls

abnormal cartilage development ( J:5109 , J:5669 )

• chondrogenesis stops earlier than in normal mice (J:5669)

endocrine/exocrine glands

small testis ( J:5109 )

♂ • testes weight at 29-32 days of age is 57% of normal