Phenotypes associated with this allele

• Allele Symbol: Pmel^si
• Allele Name: silver
• Allele ID: MGI:1857040
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmel^si/Pmel^si	Not Specified	MGI:2679566
hm2	Pmel^si/Pmel^si	STOCK a Tyrp1^b Pmel^si/J	MGI:3817199

Genotype
MGI:2679566

hm1

• Allelic Composition: Pmel^si/Pmel^si
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

reduced hair shaft melanin granule number ( J:13051 )

• Background Sensitivity: the basis for variable silvering of the coat

irregular coat pigmentation ( J:13051 , J:78801 )

• Background Sensitivity: the merle pigment pattern is difficult to classify in different crosses (J:13051)

• random inviability of melanoblasts in hair follicles results in mice that are variegated for white, partially pigmented (gray) hairs, and fully pigmented hairs (J:78801)

• other pigment loci influence appearance: nonagouti mice display silvering more on the belly than on the back and become more silvery with age, with nonagouti and brown, mice display fewer white and partially white hairs, and with agouti the yellow band at the tip of hairs is not affected but the base of each hair is lightened creating a whiteish "underfur" and silvering decreases with age (J:78801)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:29151 )

N • no aberrant bleeding time after tail vein nick

hematopoietic system

hematopoietic system phenotype ( J:29151 )

N • NORMAL: bleeding time is normal

integument

reduced hair shaft melanin granule number ( J:13051 )

• Background Sensitivity: the basis for variable silvering of the coat

irregular coat pigmentation ( J:13051 , J:78801 )

• Background Sensitivity: the merle pigment pattern is difficult to classify in different crosses (J:13051)

• random inviability of melanoblasts in hair follicles results in mice that are variegated for white, partially pigmented (gray) hairs, and fully pigmented hairs (J:78801)

• other pigment loci influence appearance: nonagouti mice display silvering more on the belly than on the back and become more silvery with age, with nonagouti and brown, mice display fewer white and partially white hairs, and with agouti the yellow band at the tip of hairs is not affected but the base of each hair is lightened creating a whiteish "underfur" and silvering decreases with age (J:78801)

Genotype
MGI:3817199

hm2

• Allelic Composition: Pmel^si/Pmel^si
• Genetic Background: STOCK a Tyrp1^b Pmel^si/J

pigmentation

pigmentation phenotype ( J:141035 )

N • mice exhibit wild-type iris pigmentation