Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lx mutation
(1 available);
any
Lx mutation
(1 available)
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embryo
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• at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward
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• posterior limb buds are narrower than in wild-type mice
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limbs/digits/tail
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• posterior limb buds are narrower than in wild-type mice
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cardiovascular system
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• at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward
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Allelic
Composition |
Lx/Lx
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Genetic
Background |
involves: fancier's silver mouse |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lx mutation
(1 available);
any
Lx mutation
(1 available)
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mortality/aging
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• some mice fail to thrive and die prior to weaning
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reproductive system
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• some mice exhibit unilateral genital agenesia
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limbs/digits/tail
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• digit abnormalities are usually bilateral and asymmetric
• the right foot is often more severely affected than the left
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• some mice have as few as 3 digits per foot
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• some mice have up to seven digits per foot
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• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing
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• the hindlimbs below the knee appear twisted
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renal/urinary system
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• some kidneys are horseshoe-shaped
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• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters
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• unilateral or bilateral
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• some mice display kidney agenesis
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behavior/neurological
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• unlike wild-type mice, when mice fall they cannot control their rotation and do not land on their feet
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• mice exhibit loss of hindlimb function that is unilateral (preferentially the right hindlimb) though occassionally bilateral
• however, mice can still walk and swim albeit slower than wild-type mice
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growth/size/body
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• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters
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skeleton
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• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing
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• reduction of presacral vertebrae
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Allelic
Composition |
Lx/Lx+
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Genetic
Background |
involves: fancier's silver mouse |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lx mutation
(1 available);
any
Lx mutation
(1 available)
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limbs/digits/tail
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• mice exhibit paraxial polydactyly in hindlimbs
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Allelic
Composition |
Dh/Dh+
Lx/Lx+
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Genetic
Background |
Not Specified |
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limbs/digits/tail
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• high incidence in compound heterozygotes
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• 13 of 20 adult compound heterozygotes have defective femora
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• 19 of 20 adult compound heterozygotes lack tibiae and the one with tibiae is hemimelic
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skeleton
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• 13 of 20 adult compound heterozygotes have defective femora
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• 19 of 20 adult compound heterozygotes lack tibiae and the one with tibiae is hemimelic
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• 2 of 20 adult compound heterozygotes have pubic bone defects
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Analysis Tools