Phenotypes associated with this allele

• Allele Symbol: hl
• Allele Name: hair loss
• Allele ID: MGI:1856901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	hl/hl	Not Specified	MGI:3767229

Genotype
MGI:3767229

hm1

• Allelic Composition: hl/hl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:13134 )

postnatal lethality, incomplete penetrance ( J:13134 , J:30767 )

• appreciable mortality seen by 2 weeks of age (J:13134)

• viability of mutant offspring from homozygous females is low (J:30767)

skeleton

abnormal skeleton physiology ( J:30767 )

abnormal bone strength ( J:30767 )

fragile skeleton ( J:30767 )

• mutant pups have broken leg and other bone fractures

• fostering pups does not ameliorate bone fragility

integument

abnormal hair growth ( J:13134 )

premature hair loss ( J:13134 )

• obvious after 5 weeks of age

• due to progressive degeneration of all hair follicles

• Background Sensitivity: hair loss may be total or partial but permanent

abnormal hair follicle morphology ( J:13134 )

abnormal hair follicle development ( J:13134 )

• there is a progressive degeneration of all hair follicles resulting in partial but permanent hair loss or entire hair loss

• Background Sensitivity: hair-loss condition is classifiable between 5 and 8 weeks of age

hair follicle degeneration ( J:13134 )

cellular

maternal effect ( J:30767 )

• young of homozygous females are more severely affected and show higher mortlity rate