All Phenotypes Ctsl<fs> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctsl^fs
furless
MGI:1856878

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsl^fs/Ctsl^fs	involves: C57BL/6 * FSB/GnEi	MGI:2450407
hm2	Ctsl^fs/Ctsl^fs	involves: C57BL/6 * unpedigreed stock	MGI:2175822

Allelic Composition	Ctsl^fs/Ctsl^fs
Genetic Background	involves: C57BL/6 * FSB/GnEi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^fs mutation (1 available); any Ctsl mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:81950 )

• 18% of tubules were atrophic, corresponding with a 12 fold increase in atrophy

decreased testis weight ( J:81950 )

• although males are fertile, a 25% weight reduction was observed in mice at 110 and 120 days of age relative to age matched control mice

reproductive system

abnormal seminiferous tubule morphology ( J:81950 )

• 18% of tubules were atrophic, corresponding with a 12 fold increase in atrophy

decreased testis weight ( J:81950 )

• although males are fertile, a 25% weight reduction was observed in mice at 110 and 120 days of age relative to age matched control mice

abnormal spermatogenesis ( J:81950 )

• 16% reduction in formation of preloptotene spermatocytes in non-atrophic tubules

• 25% reduction of complete differentiation of preloptotene spermatocytes into pachytene spermatocytes in non-atrophic tubules

Allelic Composition	Ctsl^fs/Ctsl^fs
Genetic Background	involves: C57BL/6 * unpedigreed stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^fs mutation (1 available); any Ctsl mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:5217 )

• incomplete penetrance; viability up to weaning age of furless mice is considerably reduced, but survivors are fertile; heterozygotes have normal reproductive fitness and radiation sensitivity

integument

alopecia ( J:15332 )

• age of onset is 19 days, beginning at the head and progressing toward the tail region of the back

• a new coat starts to grow at age 28 - 30 days

• mature homozygous mice are always partially devoid of hair

absent vibrissae ( J:15332 )

• vibrissae fail to penetrate the epidermis at 2 days after birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23