Phenotypes associated with this allele
Allelic
Composition |
CoblC101/CoblC101
|
|
Genetic
Background |
involves: 129/Sv * 129S2/SvPas |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CoblC101 mutation
(0 available);
any
Cobl mutation
(78 available)
|
|
|
normal phenotype
|
|
• mice are healthy and fertile with no observable phenotype
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CoblC101 mutation
(0 available);
any
Cobl mutation
(78 available)
Vangl2Lp mutation
(2 available);
any
Vangl2 mutation
(34 available)
|
|
|
nervous system
|
|
• in double homozygotes there is a rostral extension of the neural tube defect such that embryos display an open neural tube from the midbrain to the tail in 36% of the mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CoblC101 mutation
(0 available);
any
Cobl mutation
(78 available)
Vangl2Lp mutation
(2 available);
any
Vangl2 mutation
(34 available)
|
|
|
nervous system
|
|
• open neural tubes in the midbrain region
• observable by E9.5 and occurring with 20% penetrance, this phenotype was not observed in lone C101 homozygotes or lone Lp heterozygotes
|
Analysis Tools
