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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
tw8
t, wild 8
MGI:1856721
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
tw8/tw8 Not Specified MGI:3040932
ht2
thr1/tw8 Not Specified MGI:5465173


Genotype
MGI:3040932
hm1
Allelic
Composition
tw8/tw8
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
tw8 mutation (0 available); any t mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• spermatids with abnormally shaped heads are observed
• spermatids with dumbbell shaped nuclei are observed
• spermatids with abnormal microtubule formation of the manchette are observed

reproductive system
• spermatids with abnormally shaped heads are observed
• spermatids with dumbbell shaped nuclei are observed
• spermatids with abnormal microtubule formation of the manchette are observed
• many degenerating tubules with no germ cells are found in homozygotes
• males are sterile

endocrine/exocrine glands
• many degenerating tubules with no germ cells are found in homozygotes




Genotype
MGI:5465173
ht2
Allelic
Composition
thr1/tw8
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
thr1 mutation (0 available); any t mutation (19 available)
tw8 mutation (0 available); any t mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory