Phenotypes associated with this allele

• Allele Symbol: Cgct
• Allele Name: congenital cataract
• Allele ID: MGI:1856700
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cgct/Cgct	Swiss Webster	MGI:2658928
ht2	Cgct/Cgct^+	Swiss Webster	MGI:2658929
ot3	Cgct/?	Swiss Webster	MGI:7626269

Genotype
MGI:2658928

hm1

• Allelic Composition: Cgct/Cgct
• Genetic Background: Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:5298 )

Genotype
MGI:2658929

ht2

• Allelic Composition: Cgct/Cgct⁺
• Genetic Background: Swiss Webster

vision/eye

cataract ( J:5298 )

• lens opacity at 13 days of age

• Background Sensitivity: backcrosses to inbred strains and selection studies implicate a recessive modifying gene

Genotype
MGI:7626269

ot3

• Allelic Composition: Cgct/?
• Genetic Background: Swiss Webster

vision/eye

abnormal lens capsule morphology ( J:347620 )

• Generally intact but often decreased thickness

abnormal lens development ( J:347620 )

• In affected eyes lens development is disrupted beginning at E14, the nuclei of the lens fibers fade more rapidly than normal, the anterior epithelial cells that form the secondary lens fibers develop an irregular arrangement around the equatorial region and malformation with lens distortion results. By E17 vacuoles are found and worsen with development.

lens vacuoles ( J:347620 )

• At E17 pearl-like vacuoles form in the developing lens and progressive vacuolization occurs at varying rates in affected eyes

developmental cataract ( J:347620 )

• There is variability in expressivity and the cataract can appear either unilaterally or bilaterally as a dense white opacity in the lens, with the adult having many vacuoles, largest at the equatorial region, and the nuclear region being described as a clumpy eosinophilic mass with scattered calcified areas.