Phenotypes associated with this allele

• Allele Symbol: Col4a1^Bru
• Allele Name: bruised
• Allele ID: MGI:1856689
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col4a1^Bru/Col4a1^Bru	Not Specified	MGI:2658814
ht2	Col4a1^Bru/Col4a1^+	Not Specified	MGI:2658838

Genotype
MGI:2658814

hm1

• Allelic Composition: Col4a1^Bru/Col4a1^Bru
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:13980 )

• homozygotes are embryonic lethal

Genotype
MGI:2658838

ht2

• Allelic Composition: Col4a1^Bru/Col4a1⁺
• Genetic Background: Not Specified

mortality/aging

postnatal lethality, incomplete penetrance ( J:13980 )

• heterozygotes display reduced viability from birth to weaning

cardiovascular system

bruising ( J:13980 )

• at birth, heterozygotes exhibit visible bruising, sometimes around the head and sometimes around the hindquarters

growth/size/body

decreased body size ( J:13980 )

• surviving heterozygotes remain smaller than normal

vision/eye

abnormal iris morphology ( J:13980 )

anterior iris synechia ( J:13980 )

• upon slit-lamp examination, strands of tissue are shown to connect the iris, lens, and cornea

cataract ( J:13980 )

• heterozygotes display cataracts upon slit-lamp examination

buphthalmos ( J:13980 )

• surviving heterozygotes develop enlarged eyes (buphthalmos) by 1 month of age

hematopoietic system

anemia ( J:13980 )

• some heterozygotes appear pale and anemic

reproductive system

infertility ( J:13980 )

• some heterozygotes are sterile