Phenotypes associated with this allele

• Allele Symbol: Acd^acd
• Allele Name: adrenocortical dysplasia
• Allele ID: MGI:1856658
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acd^acd/Acd^acd	DW/J-Acd^acd Pou1f1^+	MGI:3796838
hm2	Acd^acd/Acd^acd	involves: DW/J	MGI:2654043

Genotype
MGI:3796838

hm1

• Allelic Composition: Acd^acd/Acd^acd
• Genetic Background: DW/J-Acd^acd Pou1f1⁺

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:18027 )

small adrenal glands ( J:18027 )

adrenal gland hypoplasia ( J:18027 )

• majority of cells have enlarged nuclei

homeostasis/metabolism

abnormal corticosterone level ( J:18027 )

decreased circulating corticosterone level ( J:18027 )

abnormal pituitary hormone level ( J:18027 )

abnormal adrenocorticotropin level ( J:18027 )

increased adrenocorticotropin level ( J:18027 )

Genotype
MGI:2654043

hm2

• Allelic Composition: Acd^acd/Acd^acd
• Genetic Background: involves: DW/J

mortality/aging

premature death ( J:14144 )

• none live beyond 6 months of age

pigmentation

hyperpigmentation ( J:14144 )

• heavy pigmentation of ears, snout, body, feet, and tail

increased ear pigmentation ( J:14144 )

• heavy ear pigmentation

increased tail pigmentation ( J:14144 )

• heavy tail pigmentation

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:14144 )

• adrenals are highly dysplastic

hearing/vestibular/ear

increased ear pigmentation ( J:14144 )

• heavy ear pigmentation

limbs/digits/tail

increased tail pigmentation ( J:14144 )

• heavy tail pigmentation

polydactyly ( J:14144 )

• polydactyly of the rear feet noticeable at birth

kinked tail ( J:14144 )

• noticeable at birth

renal/urinary system

abnormal kidney morphology ( J:14144 )

• kidney abnormalities are common

reproductive system

reduced fertility ( J:14144 )

craniofacial

increased ear pigmentation ( J:14144 )

• heavy ear pigmentation

integument

increased ear pigmentation ( J:14144 )

• heavy ear pigmentation

retarded hair growth ( J:14144 )

sparse hair ( J:14144 )

abnormal hair texture ( J:14144 )

curly vibrissae ( J:14144 )

short vibrissae ( J:14144 )

increased tail pigmentation ( J:14144 )

• heavy tail pigmentation

growth/size/body

increased ear pigmentation ( J:14144 )

• heavy ear pigmentation