Phenotypes associated with this allele

• Allele Symbol: ap
• Allele Name: alopecia periodica
• Allele ID: MGI:1856655
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	ap/ap	involves: hairless stock	MGI:2655363

Genotype
MGI:2655363

hm1

• Allelic Composition: ap/ap
• Genetic Background: involves: hairless stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal tail morphology ( J:30747 )

• during growth of the first coat, the scaly skin may form a number of rings on the tail, and the distal portion of the tail may become necrotic

tail necrosis ( J:30747 )

• the distal portion of the tail may become necrotic

vision/eye

decreased eyelid cilium number ( J:30747 )

• the eyelashes may be shortened or reduced in number

short eyelid cilia ( J:30747 )

• the eyelashes may be shortened or reduced in number

thick eyelids ( J:30747 )

• the eyelids may become thicker, possibly due to shortening and reduction in the number of eyelashes

pigmentation

abnormal coat/hair pigmentation ( J:30747 )

• after the second or more generations of the hair cycle, the black fur tone is modified into a silver tone

behavior/neurological

abnormal nursing ( J:30747 )

♀ • mutant females are fertile but show an impaired ability to suckle their young

integument

abnormal coat/ hair morphology ( J:30747 )

• all four hair types are present, but appear histologically abnormal in all hair generations

abnormal coat/hair pigmentation ( J:30747 )

• after the second or more generations of the hair cycle, the black fur tone is modified into a silver tone

abnormal hair growth ( J:30747 )

• after loss of the first coat, hair regeneration displays an abnormal antero-posterior gradient, with gradual thinning of the coat in the anterior region while the coat in the posterior region of the body is still incomplete

• loss and regeneration of hair is repeated with approx. 10-day intervals throughout life, although a less regular pattern is observed in later generations

alopecia ( J:30747 )

• mutants start shedding their first coat at 13 to 15 days after birth

• hair loss is usually complete within 20-24 days, except for some regions around the nose, toes, and tail, which retain a few hairs

short hair ( J:30747 )

• at 3-4 days after birth, the first coat is shorter than normal

sparse hair ( J:30747 )

• at 3-4 days after birth, the first coat is sparse

short vibrissae ( J:30747 )

• at 3-4 days after birth, whiskers are shorter than normal

• short whiskers are also observed in adulthood

abnormal skin appearance ( J:30747 )

• after loss of the first coat, the skin appears soft, smooth, and pinkish, until the next coat beging to grow

dry skin ( J:30747 )

• during growth of the first coat the skin appears dry

scaly skin ( J:30747 )

• during growth of the first coat the skin appears scaly

• in severe cases, these scales form rigid plates all over the body, placing the animal's life at risk

cellular

tail necrosis ( J:30747 )

• the distal portion of the tail may become necrotic