Phenotypes associated with this allele

• Allele Symbol: ptd
• Allele Name: palate-tail-digits abnormality
• Allele ID: MGI:1856624
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	ptd/ptd	either: (involves: 129S2/SvPas * C57BL/6 * BALB/c * SJL) or (involves: C57BL/6 * BALB/c * CBA * SJL)	MGI:5621177
ot2	ptd/Y	either: (involves: 129S2/SvPas * C57BL/6 * BALB/c * SJL) or (involves: C57BL/6 * BALB/c * CBA * SJL)	MGI:5620798

Genotype
MGI:5621177

hm1

• Allelic Composition: ptd/ptd
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * BALB/c * SJL) or (involves: C57BL/6 * BALB/c * CBA * SJL)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

cleft palate ( J:10812 )

digestive/alimentary system

cleft palate ( J:10812 )

growth/size/body

cleft palate ( J:10812 )

limbs/digits/tail

polydactyly ( J:10812 )

• extra digits on the hind feet

abnormal tail morphology ( J:10812 )

• appearance ranges from shortened and bent to spiraled

mortality/aging

abnormal survival ( J:10812 )

• 81% of mutant females expected from heterozygous x hemizygous matings do not reach adulthood compared with wild-type littermates

postnatal lethality, incomplete penetrance ( J:10812 )

• a proportion of deaths are due to cleft palate

embryonic lethality, incomplete penetrance ( J:10812 )

• although genotypes could not be confirmed, resorption sites in carrier mothers occurred more frequently than expected for a normal pregnancy suggesting some mutants die during embryogenesis

Genotype
MGI:5620798

ot2

• Allelic Composition: ptd/Y
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * BALB/c * SJL) or (involves: C57BL/6 * BALB/c * CBA * SJL)

mortality/aging

abnormal survival ( J:10812 )

• Background Sensitivity: 52% of mutant males expected from heterozygous x hemizygous matings do not reach adulthood compared with wild-type littermates

postnatal lethality, incomplete penetrance ( J:10812 )

• a proportion of deaths are due to cleft palate

embryonic lethality, incomplete penetrance ( J:10812 )

• although genotypes could not be confirmed, resorption sites in carrier mothers occurred more frequently than expected for a normal pregnancy suggesting some mutants die during embryogenesis

craniofacial

cleft palate ( J:10812 )

• lethal when present

limbs/digits/tail

polydactyly ( J:10812 )

• extra digits on the hind feet

abnormal tail morphology ( J:10812 )

• appearance ranges from shortened and bent to spiraled

growth/size/body

cleft palate ( J:10812 )

• lethal when present

digestive/alimentary system

cleft palate ( J:10812 )

• lethal when present