Phenotypes associated with this allele

• Allele Symbol: exf
• Allele Name: exfoliative
• Allele ID: MGI:1856601
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	exf/exf	involves: C3H/HeN(MTV^-)	MGI:4358523

Genotype
MGI:4358523

hm1

• Allelic Composition: exf/exf
• Genetic Background: involves: C3H/HeN(MTV^-)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:5649 )

• mice surviving infection are normal size and fertile

• eyes of survivors are open and normal

postnatal lethality ( J:5649 )

• 40% of mutants die between 18-19 days of age, before desquamation

• likely due to septic shock caused by Gram- bacteria present in blood and cerebrospinal fluid

growth/size/body

eyelid edema ( J:5649 )

• observed by 14 days of age and problematic until weaning; adults have transient eyelid swelling

slow postnatal weight gain ( J:5649 )

• during the exfoliative period mutant mice weigh 5 to 10% less than littermate controls but adult weights are normal

immune system

conjunctivitis ( J:5649 )

• purulent conjunctivitis begins soon after the eyes open at 13 days lasting 5 or 6 days

increased susceptibility to bacterial infection ( J:5649 )

vision/eye

eyelid edema ( J:5649 )

• observed by 14 days of age and problematic until weaning; adults have transient eyelid swelling

conjunctivitis ( J:5649 )

• purulent conjunctivitis begins soon after the eyes open at 13 days lasting 5 or 6 days

homeostasis/metabolism

eyelid edema ( J:5649 )

• observed by 14 days of age and problematic until weaning; adults have transient eyelid swelling

behavior/neurological

excessive scratching ( J:5649 )

• in response to scaling

integument

integument phenotype ( J:5649 )

N • nails are not affected

N • vibrissae are not affected

abnormal coat/ hair morphology ( J:5649 )

• mainly monotrich hairs replace a normal coat after exfoliation

• there are fewer than normal awls in hair-thinned patches of the regrown adult hair coat

abnormal hair growth ( J:5649 )

• adult mice show recurrent patches of hair loss

focal hair loss ( J:5649 )

• adults have recurrent patches of hair loss

hairless ( J:5649 )

• mutants are hairless between 29 and 30 days of age

premature hair loss ( J:5649 )

short hair ( J:5649 )

• hair regrows short and rough after exfoliation

abnormal hair texture ( J:5649 )

matted coat ( J:5649 )

• hair is ruffled and scruffy before hair and skin loss begins

rough coat ( J:5649 )

• hair regrows rough and short after exfoliation

abnormal epidermis stratum corneum morphology ( J:5649 )

• electron microscopy shows this layer is hyperkeratotic during the exfoliative period

• individual cells appear normal except for an excessive number of vacuoles

hyperkeratosis ( J:5649 )

• of the laminated stratum corneum cells during the exfoliative period

parakeratosis ( J:5649 )

• typical of the stratum corneum during the exfoliative period

impaired stratum corneum desquamation ( J:5649 )

thick epidermis stratum granulosum ( J:5649 )

• seen during the exfoliative period

acanthosis ( J:5649 )

thick epidermis stratum spinosum ( J:5649 )

• seen during the exfoliative period

scaly skin ( J:5649 )

• during exfoliation the thick laminated horney layer with hair attached shears off just above the granular layer

abnormal skin exfoliation ( J:5649 )

• during week 4 skin exfoliation and hair loss begins and spreads over the entire body

• focal points of bacterial growth are assiciated with exfoliated cells

• the thick laminated horney layer with hair attached shears off just above the granular layer

craniofacial

eyelid edema ( J:5649 )

• observed by 14 days of age and problematic until weaning; adults have transient eyelid swelling